| Semiquantitative dynamic computed tomography to predict response to anti-platelet therapy in acute cerebral infarction. | |
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MedLine Citation:
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PMID: 11914802 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated whether dynamic computed tomography (CT) in patients with acute cerebral infarction could identify patients likely to respond to anti-platelet therapy. Seventy patients underwent semiquantitative dynamic CT within 6 h as well as cerebral angiography. All then received anti-platelet therapy with a thromboxane A2 synthetase inhibitor. Peak value (pv) and time-to-peak (tp) (time-density curves) for the Sylvian fissure were extracted from dynamic CT data and standardizing interpatient data, two indices, PV/TP index and TP index, were prepared following a standard semiquantitative manner. Both PV/TP index and TP index were effective in discriminating between 48 responders (modified Rankin scale (mRS): 0 to 2) and 22 non-responders (mRS: 3 to 5, or death: 6; both P<0.0001). High PV/TP index (>or=0.8) was a strong indicator of favorable response. Most of these patients maintained regional cerebral blood flow (rCBF) via anterograde flow or collaterals, with a TP index <or=1.1. Low PV/TP index (<or=0.4) predicted non-response associated with increased TP index (>1.1) and non-compensated rCBF. Intermediate PV/TP values could not predict outcome. Dynamic CT prior to therapy can identify patients with acute cerebral infarction who are treatable with anti-platelet therapy alone. |
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Authors:
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K Chokyu; M Fukumoto; T Mori; T Mokudai; K Mori; K Shimizu |
Publication Detail:
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Type: Journal Article Date: 2002-02-02 |
Journal Detail:
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Title: Neuroradiology Volume: 44 ISSN: 0028-3940 ISO Abbreviation: Neuroradiology Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-26 Completed Date: 2002-06-20 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 1302751 Medline TA: Neuroradiology Country: Germany |
Other Details:
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Languages: eng Pagination: 286-93 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Kochi Medical School, Kohasu, Okou, Nankoku, Kochi 783-8505, Japan. choukyuu-nsu@umin.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Brain / radiography Cerebral Angiography Enzyme Inhibitors / therapeutic use* Female Humans Infarction, Middle Cerebral Artery / drug therapy, radiography* Male Methacrylates / therapeutic use* Platelet Aggregation Inhibitors / therapeutic use* Predictive Value of Tests Prognosis Thromboxane-A Synthase / antagonists & inhibitors* Tomography, X-Ray Computed* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Enzyme Inhibitors; 0/Methacrylates; 0/Platelet Aggregation Inhibitors; 82571-53-7/ozagrel; EC 5.3.99.5/Thromboxane-A Synthase |
| Comments/Corrections | |
Comment In:
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Neuroradiology. 2002 Aug;44(8):715; author reply 716-7
[PMID:
12420709
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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