| Semiquantification of the peripheral-type benzodiazepine ligand [11C]PK11195 in normal human brain and application in multiple sclerosis patients. | |
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MedLine Citation:
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PMID: 12400251 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: [11C]PK11195 is a peripheral-benzodiazepine-receptor radioligand used for detection of microglial inflammation. Normal uptake by means of semiquantification was measured in order to establish reference data. The applicability of this semiquantitative approach was tested in three multiple sclerosis patients. MATERIALS AND METHODS: Seven controls and three patients underwent MR and PET scanning. Coregistered static scans 40 minutes postinjection of [11C]PK11195 were used for assessment of relative ligand uptake by comparison to whole-brain uptake. RESULTS: For static scans acquired in near steady-state, the relative ligand uptake was significantly higher in gray matter structures as compared to the whole brain (ratio: 1.041 +/- 0.06, p = 0.036) whereas it was comparable in white matter (1.010 +/- 0.035). Intersubject reproducibility was 11.4% and 12.9% for white and grey matter. Intrasubject reproducibility was of the same order: 14.0% and 14.5% respectively. In two clinically active patients with Gadolinium-positive T1-weighted lesions on MRI the focal ligand uptake was significantly increased (1.36 and 1.14, p = 0.001). In one clinically stable patient, the uptake value corresponding with a T2-weighted MR lesion was not different from normal brain measurements. CONCLUSION: The current investigations show that normal brain uptake of [11C]PK11195 is very low and shows the feasibility of a semiquantitative method which can be applied to larger cohorts of patients subgroups. |
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Authors:
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Jan C Debruyne; Koen J Van Laere; Jan Versijpt; Filip De Vos; Johan Keppens Eng; Karel Strijckmans; Patrick Santens; Eric Achten; Guido Slegers; Jacob Korf; Rudi A Dierckx; Jacques L De Reuck |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Belgica Volume: 102 ISSN: 0300-9009 ISO Abbreviation: Acta Neurol Belg Publication Date: 2002 Sep |
Date Detail:
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Created Date: 2002-10-28 Completed Date: 2003-02-13 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0247035 Medline TA: Acta Neurol Belg Country: Belgium |
Other Details:
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Languages: eng Pagination: 127-35 Citation Subset: IM |
Affiliation:
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Department of Neurology, Ghent University Hospital, Ghent, Belgium. jan.debruyne@rug.ac.be |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Benzodiazepines Brain / radionuclide imaging* Female Humans Isoquinolines / pharmacokinetics* Ligands Magnetic Resonance Imaging Male Multiple Sclerosis / metabolism, radiography, radionuclide imaging* Reproducibility of Results Tomography, Emission-Computed |
| Chemical | |
Reg. No./Substance:
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0/Isoquinolines; 0/Ligands; 12794-10-4/Benzodiazepines; 85340-56-3/PK 11195 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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