| Semipermeable dressings improve epidermal barrier function in premature infants. | |
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MedLine Citation:
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PMID: 7808826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Infants of less than 32 wk gestation have a defective epidermal barrier, with increased skin permeability and transepidermal water loss (TEWL). We studied the effect of a nonadhesive semipermeable dressing on the epidermal barrier of premature infants and on fetal skin transplanted to nude mice. Fifteen infants with a mean estimated gestational age of 27.7 wk and 16 human fetal skin grafts (estimated gestational age, 23-26 wk) transplanted to eight nude mice were studied. One lower leg (or skin graft) was treated and the other left untreated as a control. In the infants, TEWL was measured on control skin and treated skin (both through the dressing and after temporary dressing removal) on d 0, 1, 2, 4, and 7. Bacterial and fungal cultures were also performed. In the mice, TEWL and skin blood flow were measured on d 0, 2, and 4. Biopsies were obtained on d 4 for a cell proliferation assay, histology, and electron microscopy. Treated infant skin showed a consistently lower bacterial number and a significantly decreased TEWL (measured through the dressing). There was also a significantly lower TEWL on the treated side, measured after temporary dressing removal, on d 1, 2, 4, and 7, documenting improved epidermal barrier function. The animal study revealed decreased TEWL and a nearly 2-fold greater d-4 keratinocyte proliferation (p = 0.01) in treated skin and decreased blood flow on d 4 in control skin (p = 0.01). There was no significant difference in the volume density of membrane coating granules or the morphology of intercorneocyte spaces.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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A J Mancini; S Sookdeo-Drost; K C Madison; B R Smoller; A T Lane |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pediatric research Volume: 36 ISSN: 0031-3998 ISO Abbreviation: Pediatr. Res. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1995-02-02 Completed Date: 1995-02-02 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0100714 Medline TA: Pediatr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 306-14 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Stanford University School of Medicine, California 94305-5486. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bandages* Cell Division / physiology Epidermis / metabolism* Female Fetal Tissue Transplantation / physiology Histological Techniques Humans Infant, Newborn Infant, Premature / metabolism* Keratinocytes / cytology Male Mice Mice, Nude Microscopy, Electron Permeability Regional Blood Flow Skin / blood supply Skin Transplantation / physiology |
| Grant Support | |
ID/Acronym/Agency:
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RR00081/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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