Document Detail

Seminal vesicle intrafraction motion analysed with cinematic magnetic resonance imaging.
MedLine Citation:
PMID:  25106679     Owner:  NLM     Status:  In-Process    
PURPOSE: This study analyses seminal vesicle displacement relative to the prostate and in relation to treatment time.
METHOD: A group of eleven patients undergoing prostate cancer radiotherapy were imaged with a continuous 3 T cine-MRI in the standard treatment setup position. Four images were recorded every 4 seconds for 15 minutes in the sagittal plane and every 6.5 seconds for 12 minutes in the coronal plane. The prostate gland and seminal vesicles were contoured on each MRI image. The coordinates of the centroid of the prostate and seminal vesicles on each image was analysed for displacement against time. Displacements between the 2.5 percentile and 97.5 percentile (i.e. the 2.5% trimmed range) for prostate and seminal vesicle centroid displacements were measured for 3, 5, 10 and 15 minutes time intervals in the anterior-posterior (AP), left-right (LR) and superior-inferior (SI) directions. Real time prostate and seminal vesicle displacement was compared for individual patients.
RESULTS: The 2.5% trimmed range for 3, 5, 10 and 15 minutes for the seminal vesicle centroids in the SI direction measured 4.7 mm; 5.8 mm; 6.5 mm and 7.2 mm respectively. In the AP direction, it was 4.0 mm, 4.5 mm, 6.5 mm, and 7.0 mm. In the LR direction for 3, 5 and 10 minutes; for the left seminal vesicle, it was 2.7 mm, 2.8 mm, 3.4 mm and for the right seminal vesicle, it was 3.4 mm, 3.3 mm, and 3.4 mm. The correlation between the real-time prostate and seminal vesicle displacement varied substantially between patients indicating that the relationship between prostate displacement and seminal vesicles displacement is patient specific with the majority of the patients not having a strong relationship.
CONCLUSION: Our study shows that seminal vesicle motion increases with treatment time, and that the prostate and seminal vesicle centroids do not move in unison in real time, and that an additional margin is required for independent seminal vesicle motion if treatment localisation is to the prostate.
Suki Gill; Kim Dang; Chris Fox; Mathias Bressel; Tomas Kron; Noelene Bergen; Nick Ferris; Rebecca Owen; Sarat Chander; Keen Hun Tai; Farshad Foroudi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2014-08-08
Journal Detail:
Title:  Radiation oncology (London, England)     Volume:  9     ISSN:  1748-717X     ISO Abbreviation:  Radiat Oncol     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-29     Completed Date:  -     Revised Date:  2014-12-03    
Medline Journal Info:
Nlm Unique ID:  101265111     Medline TA:  Radiat Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  174     Citation Subset:  IM    
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