| Seminal leukocytes are Good Samaritans for spermatozoa. | |
| | |
MedLine Citation:
|
PMID: 22047665 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the effect of leukocytospermia on assisted reproductive technology outcomes. DESIGN: Retrospective analysis. SETTING: University laboratory. PATIENT(S): Couples attending the infertiliy clinic and involved in ART program for IVF or ICSI. INTERVENTION(S): During a 7-year follow-up in an assisted reproductive technology program, leukocytospermia was routinely determined using the peroxidase technique. Donor sperm were excluded from the study. MAIN OUTCOME MEASURE(S): Egg retrievals (N = 3,508) were distributed in 3 groups according to the leukocyte levels in semen from which fertilizing sperm were extracted: group 1, absence of leukocytes (n = 3,026); group 2, moderate leukocytospermia (<10(6)/mL) (n = 344); or group 3, high leukocytospermia (≥10(6)/mL) (n = 138). They resulted in 1,463 IVF and 2,045 intracytoplasmic sperm injection procedures that gave 802 clinical pregnancies. RESULT(S): Surprisingly, the fertilization rate, cleavage rate, clinical pregnancy rate, gestational age, and mean infant weight were significantly improved when seminal leukocytes were present, regardless of the technique used. The only negative side effects associated with a high level of seminal leukocytes (group 3) were an elevated rate of early pregnancy loss (from 26.6% to 40.5%) and a 3-fold increase in the percentage of ectopic pregnancies. CONCLUSION(S): At moderate levels (<10(6)/mL), leukocytospermia appears to be physiologic. It is associated with improved sperm fertilization ability and pregnancy outcome. At higher concentrations, leukocytospermia alters neither sperm fertilization ability nor the probability of clinical pregnancy when compared with nonleukocytic patients with infertility. However, the pregnancy outcome is reduced. |
| | |
Authors:
|
Virginie Barraud-Lange; Jean-Christophe Pont; Ahmed Ziyyat; Khaled Pocate; Christophe Sifer; Isabelle Cedrin-Durnerin; Bouchra Fechtali; Beatrice Ducot; Jean Philippe Wolf |
Related Documents
:
|
22024135 - Prenatal exposure to lipopolysaccharide results in neurodevelopmental damage that is am... 21637365 - Body mass index impacts in vitro fertilization stimulation. 21656645 - Adverse influence of coumestrol on secretory function of bovine luteal cells in the fir... 21807365 - Comparison of in vitro fertilization/intracytoplasmic sperm injection outcomes in male... 6464315 - Factors responsible for post parturient metritis in dairy cattle. 21352205 - Incomplete activation of peripheral blood dendritic cells during healthy human pregnancy. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-1 |
Journal Detail:
|
Title: Fertility and sterility Volume: - ISSN: 1556-5653 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-3 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Service d'Histologie-Embryologie-Biologie de la Reproduction, Hôpital Cochin, Université Paris Descartes, Paris, France; Inserm U1016, Institut Cochin, Université Paris Descartes, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intrauterine injection of human chorionic gonadotropin before embryo transfer significantly improves...
Next Document: Mutations in PMCA2 and hereditary deafness: A molecular analysis of the pump defect.