Document Detail


Semiconserved regulation of mesendoderm differentiation by microRNAs.
MedLine Citation:
PMID:  19386256     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MicroRNAs are known to play important roles in many different processes. However, their roles in shaping the early steps in embryogenesis have remained largely hidden. In this issue of Developmental Cell, Rosa et al. show that the miR-430/427/302 family of microRNAs has a distinct effect on Nodal signaling, affecting mesendoderm differentiation in Xenopus embryos and human embryonic cell lines.
Authors:
René F Ketting
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Publication Detail:
Type:  Comment; Journal Article    
Journal Detail:
Title:  Developmental cell     Volume:  16     ISSN:  1878-1551     ISO Abbreviation:  Dev. Cell     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-23     Completed Date:  2009-05-15     Revised Date:  2009-05-22    
Medline Journal Info:
Nlm Unique ID:  101120028     Medline TA:  Dev Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-8     Citation Subset:  IM    
Affiliation:
Hubrecht Institute-KNAW and University Medical Centre Utrecht, Utrecht, The Netherlands. r.ketting@hubrecht.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation*
Cell Lineage / drug effects
Endoderm / cytology*,  drug effects,  embryology,  metabolism
Humans
Mesoderm / cytology*,  drug effects,  embryology,  metabolism
MicroRNAs / genetics,  metabolism*
Oligonucleotides, Antisense / pharmacology
Species Specificity
Xenopus laevis / embryology,  genetics
Chemical
Reg. No./Substance:
0/MIRN302 microRNA, human; 0/MicroRNAs; 0/Oligonucleotides, Antisense
Comments/Corrections
Comment On:
Dev Cell. 2009 Apr;16(4):517-27   [PMID:  19386261 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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