Document Detail


Semicircadian rhythms of c-Fos expression in several hypothalamic areas during pregnancy in the rat: relationship to prolactin secretion.
MedLine Citation:
PMID:  9508038     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prolactin (PRL) serves an important luteotrophic function in the rat during early pregnancy, expressed as a nocturnal surge in the early morning and a diurnal surge in the late afternoon. Several areas of the hypothalamus, including the preoptic area (POA), the suprachiasmatic nucleus (SCN) and the ventromedial and dorsomedial nuclei (VM-DM) have been implicated in PRL surges. We investigated the temporal relationship between neuronal activity as measured by c-Fos immunocytochemistry in these areas and PRL secretion during early and late pregnancy. Brains were collected at nine time points (24:00, 02:00, 04:00, 06:00, 10:00, 14:00, 16:00, 18:00 and 20:00 h) on days 6-7 and three time points (02:00, 14:00 and 18:00 h) on days 14-15 of pregnancy. Plasma PRL levels determined by radioimmunoassay revealed two surges with peaks at 02:00 and 18:00 h and a trough at 14:00 h on days 6-7, which were absent on days 14-15 of pregnancy. The number of neurons expressing c-Fos in the anterior medial preoptic nucleus, the medial preoptic area and the medial preoptic nucleus, but not the anteroventral preoptic nucleus of the POA, and the VM-DM, showed a semicircadian rhythm which was maximal at 02:00 h or/and 04:00 and 18:00 h and reached the lowest value at 14:00 h, in parallel with the PRL surges in early pregnancy. However, the temporal pattern of c-Fos in these areas was reversed during late pregnancy, with a peak at 14:00 h and low levels at 02:00 and 18:00 h. PRL surges were absent and levels were uniformly low during these times. Neuronal activity in the SCN did not show any correlation with PRL surges. The dorsomedial subdivision of the SCN showed high neuronal activity during the daytime in both stages of pregnancy. Neuronal activity in the ventrolateral subdivision of the SCN was high during the nighttime in early pregnancy, however it exhibited high levels during the daytime in late pregnancy. These results suggest that the two daily surges of PRL secretion during the first half of pregnancy might be related to the temporal rhythm of neuronal activity in the POA and the VM-DM, and a major change in the pattern of neuronal activity in these hypothalamic areas might result in termination of the PRL surges at midpregnancy.
Authors:
Y Lee; L A Arbogast; J L Voogt
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroendocrinology     Volume:  67     ISSN:  0028-3835     ISO Abbreviation:  Neuroendocrinology     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-09     Completed Date:  1998-04-09     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  83-93     Citation Subset:  IM    
Affiliation:
Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City 66160-7401, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Circadian Rhythm*
Female
Gene Expression*
Genes, fos / genetics*
Hypothalamus / metabolism*
Hypothalamus, Middle / metabolism
Male
Neurons / metabolism
Pregnancy
Pregnancy, Animal / metabolism*
Preoptic Area / metabolism
Prolactin / blood,  secretion*
Rats
Rats, Sprague-Dawley
Suprachiasmatic Nucleus / metabolism
Grant Support
ID/Acronym/Agency:
HD-24190/HD/NICHD NIH HHS; HD-33994/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
9002-62-4/Prolactin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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