Document Detail


Semicarbazide-sensitive amine oxidase activity and total nitrite and nitrate concentrations in serum: novel biochemical markers for type 2 diabetes?
MedLine Citation:
PMID:  18853098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to evaluate the activity of semicarbazide-sensitive amine oxidase (SSAO) and the total nitrite and nitrate (NO( x )) concentrations in serum from type 2 diabetic patients and control subjects in order to evaluate if they could be used as novel diabetic markers. We studied 38 type 2 diabetic patients and 35 control subjects. Serum samples from those subjects were evaluated by radiochemical methods for SSAO activity using (14)C-benzylamine. Serum NO( x ) concentrations were obtained as an index of nitric oxide production by the Griess reaction. Serum SSAO activity was higher in type 2 diabetic patients than in control group and serum SSAO in type 2 diabetic correlated with age, serum creatinine and total cholesterol. Serum NO( x ) levels in type 2 diabetic patients were also significantly higher than those in the control group. Serum NO( x ) levels in control group correlated with serum SSAO activity. In conclusion, the increase in the SSAO activity and NO( x ) levels observed in type 2 diabetic patients could be parameters to take in account and play relevant role in diabetes development. SSAO and NO( x ) are suggested as markers for prognostic of diabetes.
Authors:
Sandra Fernanda Nunes; Isabel Vitoria Figueiredo; Paulo João Soares; Nuria Espriu Costa; Maria Celeste Lopes; Maria Margarida Caramona
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-10-14
Journal Detail:
Title:  Acta diabetologica     Volume:  46     ISSN:  1432-5233     ISO Abbreviation:  Acta Diabetol     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-07-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200299     Medline TA:  Acta Diabetol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  135-40     Citation Subset:  IM    
Affiliation:
Laboratory of Pharmacology, Faculty of Pharmacy, University of Coimbra, 3000-175, Coimbra, Portugal.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Aged
Aged, 80 and over
Albuminuria / epidemiology
Amine Oxidase (Copper-Containing) / blood*
Biological Markers / blood*
Blood Glucose / metabolism
Cholesterol / blood
Diabetes Mellitus, Type 2 / blood*,  drug therapy,  enzymology
Female
Hemoglobin A, Glycosylated / metabolism
Humans
Hypoglycemic Agents / administration & dosage,  therapeutic use
Male
Middle Aged
Nitrates / blood*
Nitric Oxide / blood*
Nitrites / blood*
Prognosis
Reference Values
Reproducibility of Results
Triglycerides / blood
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Hemoglobin A, Glycosylated; 0/Hypoglycemic Agents; 0/Nitrates; 0/Nitrites; 0/Triglycerides; 10102-43-9/Nitric Oxide; 57-88-5/Cholesterol; EC 1.4.3.6/Amine Oxidase (Copper-Containing)

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