Document Detail

Semicarbazide is non-specific as a marker metabolite to reveal nitrofurazone abuse as it can form under Hofmann conditions.
MedLine Citation:
PMID:  18608513     Owner:  NLM     Status:  Publisher    
Detecting illegal nitrofurazone treatment of food-producing animals has been undermined by the reliance on semicarbazide as a marker metabolite for analysis because, during processing, semicarbazide forms in a variety of foods not exposed to nitrofurazone by previously unexplained pathways. In this study, formation of semicarbazide was examined under dairy product processing conditions. Hypochlorite dosed into milk on an industrial scale, at concentrations extreme for unintentional residues, produced monochloramine, but, without pH adjustment, hypochlorite alone did not generate semicarbazide. Dosed hypochlorite and peroxyacetic acid each generated low ng g(-1) levels of semicarbazide in milk (and whey) only when used in conjunction with localised high pH conditions, which can occur during both anion exchange and neutralisation. Dosed hydroxyurea generated semicarbazide at any pH, with greatest levels formed at high pH. Detecting nitrofurazone abuse can be better accomplished by analysis either for nitrofurazone itself or for the marker metabolite 5-nitro-2-furaldehyde, rather than semicarbazide.
Justin G Bendall
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2008-6-12
Journal Detail:
Title:  Food additives and contaminants     Volume:  -     ISSN:  1464-5122     ISO Abbreviation:  Food Addit Contam     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-7-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500474     Medline TA:  Food Addit Contam     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-10     Citation Subset:  -    
Fonterra Research Centre, Palmerston North, New Zealand.
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