| Semi-quantitative gallium-67 lung scanning as a measure of the intensity of alveolitis in pulmonary sarcoidosis. | |
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MedLine Citation:
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PMID: 3769966 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gallium-67 (67Ga) lung scanning has been applied for some years in pulmonary sarcoidosis to assess the activity of the alveolitis. Interpreting the scans, however, is difficult due to the low uptake of 67Ga in the disease process relative to background activity. In this study we have measured the mean parenchymal lung activity of 67Ga and have compared the lung activity to that at three remote sites, the liver, the abdomen and the thigh. The results obtained were compared with the percentage of lymphocytes in broncho-alveolar lavage fluid. There was a very good correlation with the lung-to-thigh uptake measurements and a much poorer correlation with the lung-to-liver and the lung-to-abdomen measurements. It was observed that steroid therapy reduced dramatically the correlation between the broncho-alveolar lavage findings and the 67Ga scan measurements. The results suggest that in patients not on steroid therapy, the 67Ga lung-to-thigh measurements may be used, similarly to the broncho-alveolar lavage lymphocyte counts, to identify those with high-intensity alveolitis from those with low-intensity alveolitis. |
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Authors:
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G J Duffy; K Thirumurthi; M Casey; F Barker; N Brennan; C Odlum; M X Fitzgerald |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of nuclear medicine Volume: 12 ISSN: 0340-6997 ISO Abbreviation: Eur J Nucl Med Publication Date: 1986 |
Date Detail:
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Created Date: 1986-12-05 Completed Date: 1986-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7606882 Medline TA: Eur J Nucl Med Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 187-91 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Gallium Radioisotopes / diagnostic use* Humans Lung Diseases / complications, drug therapy, radionuclide imaging* Lymphocytes / analysis Male Middle Aged Pulmonary Fibrosis / etiology, pathology, radionuclide imaging* Sarcoidosis / complications, drug therapy, radionuclide imaging* Steroids / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Gallium Radioisotopes; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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