| Semi-automatic stereotactic coordinate identification algorithm for routine localization of Deep Brain Stimulation electrodes. | |
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MedLine Citation:
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PMID: 20036691 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Deep Brain Stimulation (DBS) is a routine therapy for movement disorders, and has several emerging indications. We present a novel protocol to define the stereotactic coordinates of metallic DBS implants that may be routinely employed for validating therapeutic anatomical targets. Patients were referred for troubleshooting or new DBS implantation. A volumetric MRI of the brain obtained prior to or during this protocol was formatted to the Anterior Commissure-Posterior Commissure (AC-PC) coordinate system. Patients underwent a CT scan of the brain in an extended Hounsfield unit (EHU) mode. A semi-automatic detection algorithm based on a Normalized Mutual Information (NMI) co-registration method was implemented to measure the AC-PC coordinates of each DBS contact. This algorithm was validated using manual DBS contact identification. Fifty MRI-CT image pairs were available in 39 patients with a total of 336 DBS electrodes. The median and mean Euclidean distance errors for automatic identification of electrode locations were 0.20mm and 0.22 mm, respectively. This method is an accurate method of localization of active DBS contacts within the sub-cortical region. As the investigational indications of DBS expand, this method may be used for verification of final implant coordinates, critical for understanding clinical benefit and comparing efficacy between subjects. |
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Authors:
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Adam O Hebb; Kai J Miller |
Publication Detail:
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Type: Journal Article; Validation Studies Date: 2009-12-29 |
Journal Detail:
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Title: Journal of neuroscience methods Volume: 187 ISSN: 1872-678X ISO Abbreviation: J. Neurosci. Methods Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905558 Medline TA: J Neurosci Methods Country: Netherlands |
Other Details:
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Languages: eng Pagination: 114-9 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Neurosurgery, University of Washington, Seattle, WA 98195, United States. aohebb@u.washington.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms* Automation* Brain / pathology, radiography Deep Brain Stimulation / instrumentation*, methods* Electrodes, Implanted* Humans Information Theory Magnetic Resonance Imaging Stereotaxic Techniques* Tomography, X-Ray Computed / methods |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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