Document Detail


Semen quality and fertility in adult long-term survivors of childhood acute lymphoblastic leukemia.
MedLine Citation:
PMID:  21868007     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To assess testicular function and its determinants in adult survivors of childhood acute lymphoblastic leukemia (ALL) at a median time of 20 years after ALL therapy.
DESIGN: Prospective investigation.
SETTING: University hospital.
PATIENT(S): Fifty-one male long-term survivors and 56 age-matched controls (median age of survivors at ALL diagnosis was 5 years, range: 1 to 15 years, and at the study 29 years, range: 26 to 38 years).
INTERVENTION(S): None.
MAIN OUTCOME MEASURE(S): Testicular size (mean value of both testicular volumes), serum hormone concentrations, semen quality, and number of children fathered correlated with ALL therapy.
RESULT(S): Survivors treated with 0-10 g/m(2) of cyclophosphamide had sperm quality and fertility rates comparable with those of controls, but the serum free-testosterone in the survivors treated with cyclophosphamide was lower than in controls (median: 213 pmol/L, range: 189-260 vs. 296 pmol/L, range: 242-338, respectively). Cranial irradiation without cyclophosphamide did not affect semen quality, fertility, or testosterone levels. None of the survivors of a high cumulative dose of cyclophosphamide (>20 g/m(2)) and testicular irradiation (10-24 Gy) had fathered a child. Testicular size was shown to be better than serum inhibin B in predicting nonazoospermic semen samples or fertility.
CONCLUSION(S): Treatment of childhood ALL with 0-10 g/m(2) of cyclophosphamide and cranial irradiation does not affect fertility or semen quality but may impair long-term Leydig cell function.
Authors:
Kirsi Jahnukainen; Risto Heikkinen; Markus Henriksson; Trevor G Cooper; Leena-Riitta Puukko-Viertomies; Outi Mäkitie
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-08-24
Journal Detail:
Title:  Fertility and sterility     Volume:  96     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-03     Completed Date:  2011-11-29     Revised Date:  2012-09-11    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  837-42     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Affiliation:
Division of Hematology-Oncology and Stem Cell Transplantation, Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. kirsi.jahnukainen@ki.se
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MeSH Terms
Descriptor/Qualifier:
Adult
Cohort Studies
Cyclophosphamide / pharmacology,  therapeutic use
Fertility* / drug effects,  radiation effects
Humans
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma / drug therapy*,  epidemiology,  radiotherapy*
Prospective Studies
Semen / drug effects,  radiation effects
Semen Analysis / methods*
Survivors*
Testis / drug effects,  radiation effects
Chemical
Reg. No./Substance:
50-18-0/Cyclophosphamide
Comments/Corrections
Comment In:
J Urol. 2012 Aug;188(2):554-5   [PMID:  22784755 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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