| Semen quality according to prenatal coffee and present caffeine exposure: two decades of follow-up of a pregnancy cohort. | |
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MedLine Citation:
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PMID: 18757446 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: A few studies have investigated the association between male caffeine consumption in adult life and semen quality with conflicting results, but so far no studies have explored the effect of prenatal coffee exposure. We studied the association between prenatal coffee and current caffeine exposure and semen quality and levels of reproductive hormones. METHODS: From a Danish pregnancy cohort established in 1984-1987, 347 sons out of 5109 were selected for a follow-up study conducted 2005-2006. Semen and blood samples were analyzed for conventional semen characteristics and reproductive hormones and were related to information on maternal coffee consumption during pregnancy and present caffeine consumption. Data were available for 343 men. RESULTS: There was a tendency toward decreasing crude median semen volume (P = 0.06) and adjusted mean testosterone (P = 0.06) and inhibin B (P = 0.09) concentrations with increasing maternal coffee consumption during pregnancy. Sons of mothers drinking 4-7 cups/day had lower testosterone levels than sons of mothers drinking 0-3 cups/day (P = 0.04). Current male caffeine intake was associated with increasing testosterone levels (P = 0.007). Men with a high caffeine intake had approximately 14% higher concentration of testosterone than those with a low caffeine intake (P = 0.008). CONCLUSIONS: The results observed in this study are only tentative, but they do not exclude a small to moderate effect of prenatal coffee exposure on semen volume and levels of reproductive hormones. Present adult caffeine intake did not show any clear associations with semen quality, but high caffeine intake was associated with a higher testosterone concentration. |
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Authors:
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C H Ramlau-Hansen; A M Thulstrup; J P Bonde; J Olsen; B H Bech |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-28 |
Journal Detail:
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Title: Human reproduction (Oxford, England) Volume: 23 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-18 Completed Date: 2009-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
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Languages: eng Pagination: 2799-805 Citation Subset: IM |
Affiliation:
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Department of Occupational Medicine, Aarhus University Hospital, Aarhus C, Denmark. craha@as.aaa.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Caffeine / pharmacology* Coffee* Female Follow-Up Studies Humans Inhibins / blood Male Maternal-Fetal Exchange Pregnancy Prenatal Exposure Delayed Effects Semen / drug effects Semen Analysis* Sperm Count Testosterone / blood |
| Chemical | |
Reg. No./Substance:
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0/Coffee; 0/inhibin B; 57285-09-3/Inhibins; 58-08-2/Caffeine; 58-22-0/Testosterone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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