| Semaphorin3D guides retinal axons along the dorsoventral axis of the tectum. | |
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MedLine Citation:
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PMID: 14724229 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We examined the role of Sema3D, a semaphorin of previously unknown function, in guiding retinal ganglion cell (RGC) axons to the optic tectum in the developing zebrafish. Sema3D is expressed more strongly in the ventral versus dorsal tectum, suggesting that it may participate in guiding RGC axons along the dorsoventral axis of the tectum. Ubiquitous misexpression of Sema3D in transgenic zebrafish inhibits ventral but not dorsal RGC axon growth. In addition, ventral RGC axons avoid or stop at individual cells misexpressing Sema3D along their pathway. Sema3D ubiquitous misexpression at later stages also causes ventral RGC axon arbors to spread more widely along the dorsoventral axis of the tectum. Knock-down of Sema3D with morpholino antisense causes ventral RGC axons to extend aberrantly into the ventral tectum. These results suggest that Sema3D in the ventral tectum normally acts to inhibit ventral RGCs from extending into ventral tectum, ensuring their correct innervation of dorsal tectum. |
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Authors:
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Yan Liu; Jason Berndt; Fengyun Su; Hiroshi Tawarayama; Wataru Shoji; John Y Kuwada; Mary C Halloran |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of neuroscience : the official journal of the Society for Neuroscience Volume: 24 ISSN: 1529-2401 ISO Abbreviation: J. Neurosci. Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-15 Completed Date: 2004-02-11 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8102140 Medline TA: J Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 310-8 Citation Subset: IM |
Affiliation:
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Department of Zoology and Anatomy, University of Wisconsin, Madison, Wisconsin 53706, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antisense Elements (Genetics) Axons / ultrastructure* Carrier Proteins / genetics, physiology* Nerve Tissue Proteins / genetics, physiology* Neuropilins / metabolism Organisms, Genetically Modified Retina / embryology* Retinal Ganglion Cells / cytology* Semaphorins / genetics, physiology* Superior Colliculi / cytology*, embryology, metabolism Visual Pathways / cytology, embryology Zebrafish / anatomy & histology, embryology, genetics |
| Grant Support | |
ID/Acronym/Agency:
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NS36587/NS/NINDS NIH HHS; NS42228/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antisense Elements (Genetics); 0/Carrier Proteins; 0/Nerve Tissue Proteins; 0/Neuropilins; 0/Semaphorins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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