| Semaphorin signaling: molecular switches at the midline. | |
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MedLine Citation:
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PMID: 20655749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents. How a navigating growth cone responds to a specific semaphorin is not absolute but instead depends on the biological context in which this cue is encountered. Here we review recent breakthroughs in our understanding of the extrinsic signals and molecular processes that control growth cone responses to class 3 semaphorins (Sema3s) at a well-characterized intermediate target, the spinal cord midline. |
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Authors:
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Alwin A H A Derijck; Susan Van Erp; R Jeroen Pasterkamp |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-07-23 |
Journal Detail:
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Title: Trends in cell biology Volume: 20 ISSN: 1879-3088 ISO Abbreviation: Trends Cell Biol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-03 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9200566 Medline TA: Trends Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 568-76 Citation Subset: IM |
Copyright Information:
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Copyright 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Axons / metabolism Growth Cones Mice Semaphorins / metabolism* Signal Transduction* Spinal Cord / cytology, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Semaphorins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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