Document Detail


Semaphorin signaling: molecular switches at the midline.
MedLine Citation:
PMID:  20655749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To establish axonal connections growth cones must navigate multiple intermediate targets before reaching their final target. During this journey growth cones are guided by extracellular repulsive and attractive signals. Although initially identified as repulsive molecules, members of the semaphorin family include both attractants and repellents. How a navigating growth cone responds to a specific semaphorin is not absolute but instead depends on the biological context in which this cue is encountered. Here we review recent breakthroughs in our understanding of the extrinsic signals and molecular processes that control growth cone responses to class 3 semaphorins (Sema3s) at a well-characterized intermediate target, the spinal cord midline.
Authors:
Alwin A H A Derijck; Susan Van Erp; R Jeroen Pasterkamp
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-07-23
Journal Detail:
Title:  Trends in cell biology     Volume:  20     ISSN:  1879-3088     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-03     Completed Date:  2010-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  568-76     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / metabolism
Growth Cones
Mice
Semaphorins / metabolism*
Signal Transduction*
Spinal Cord / cytology,  metabolism*
Chemical
Reg. No./Substance:
0/Semaphorins

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