Document Detail

Semantic dementia and persisting Wernicke's aphasia: linguistic and anatomical profiles.
MedLine Citation:
PMID:  21315437     Owner:  NLM     Status:  MEDLINE    
Few studies have directly compared the clinical and anatomical characteristics of patients with progressive aphasia to those of patients with aphasia caused by stroke. In the current study we examined fluent forms of aphasia in these two groups, specifically semantic dementia (SD) and persisting Wernicke's aphasia (WA) due to stroke. We compared 10 patients with SD to 10 age- and education-matched patients with WA in three language domains: language comprehension (single words and sentences), spontaneous speech and visual semantics. Neuroanatomical involvement was analyzed using disease-specific image analysis techniques: voxel-based morphometry (VBM) for patients with SD and overlays of lesion digitized lesion reconstructions in patients with WA. Patients with SD and WA were both impaired on tasks that involved visual semantics, but patients with SD were less impaired in spontaneous speech and sentence comprehension. The anatomical findings showed that different regions were most affected in the two disorders: the left anterior temporal lobe in SD and the left posterior middle temporal gyrus in chronic WA. This study highlights that the two syndromes classically associated with language comprehension deficits in aphasia due to stroke and neurodegenerative disease are clinically distinct, most likely due to distinct distributions of damage in the temporal lobe.
J M Ogar; J V Baldo; S M Wilson; S M Brambati; B L Miller; N F Dronkers; M L Gorno-Tempini
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-02-18
Journal Detail:
Title:  Brain and language     Volume:  117     ISSN:  1090-2155     ISO Abbreviation:  Brain Lang     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-04-12     Completed Date:  2011-08-05     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  7506220     Medline TA:  Brain Lang     Country:  United States    
Other Details:
Languages:  eng     Pagination:  28-33     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Aphasia, Wernicke / pathology*,  physiopathology
Auditory Perceptual Disorders / etiology,  pathology,  physiopathology
Brain / pathology*,  physiopathology
Frontotemporal Lobar Degeneration / pathology*,  physiopathology
Middle Aged
Neuropsychological Tests
Retrospective Studies
Grant Support
5 P01 NS040813/NS/NINDS NIH HHS; 5 R01 DC00216/DC/NIDCD NIH HHS; P01 AG019724/AG/NIA NIH HHS; P50 AG03006/AG/NIA NIH HHS; R01 NS050915/NS/NINDS NIH HHS; R01 NS050915/NS/NINDS NIH HHS; R01 NS050915-07/NS/NINDS NIH HHS; R03 DC010878/DC/NIDCD NIH HHS; R03 DC010878-04/DC/NIDCD NIH HHS

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