Document Detail


Self-specific processing in the default network: a single-pulse TMS study.
MedLine Citation:
PMID:  20878395     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In examining neural processing specific to the self, primarily by contrasting self-related stimuli with non-self-related stimuli (i.e., self vs. other), neuroimaging studies have activated a consistent set of regions, including medial prefrontal cortex (MPFC), precuneus, and right and left inferior parietal cortex. However, criticism has arisen that this network may not be specific to self-related processing, but instead reflects a more general aspect of cortical processing. For example, it is almost identical to the active network of the resting state, the "default" mode, when the subject is free to think about anything at all. We tested the self-specificity of this network by using transcranial magnetic stimulation (TMS) to briefly disrupt local cortical processing while subjects rated adjectives as like or unlike themselves or their best friend. Healthy volunteers show a self-reference effect (SRE) in this task, in which performance with self-related items is superior to that with other-related items. As individual adjectives appeared on a monitor, single-pulse TMS was applied at five different times relative to stimulus onset (SOA: stimulus onset asynchrony) ranging from 0 to 480 ms. In 18 subjects, TMS to left parietal cortex suppressed the SRE from 160 to 480 ms. SRE suppression occurred at later SOA with TMS to the right parietal cortex. In contrast, no effects were seen with TMS to MPFC. Together with our previous work, these results provide evidence for a self-specific processing system in which midline and lateral inferior parietal cortices, as elements of the default network, play a role in ongoing self-awareness.
Authors:
Hans C Lou; Bruce Luber; Arielle Stanford; Sarah H Lisanby
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Publication Detail:
Type:  Journal Article     Date:  2010-09-29
Journal Detail:
Title:  Experimental brain research     Volume:  207     ISSN:  1432-1106     ISO Abbreviation:  Exp Brain Res     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-10-27     Completed Date:  2011-02-04     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  0043312     Medline TA:  Exp Brain Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  27-38     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Attention / physiology
Brain / physiology*
Female
Humans
Male
Nerve Net / physiology*
Personality / physiology
Photic Stimulation
Psychomotor Performance / physiology
Reaction Time / physiology
Self Concept*
Transcranial Magnetic Stimulation
Grant Support
ID/Acronym/Agency:
K23 MH076976/MH/NIMH NIH HHS; K23 MH076976-01A1/MH/NIMH NIH HHS; L30 MH072461/MH/NIMH NIH HHS; L30 MH072461-01/MH/NIMH NIH HHS
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