| Self-reported oral dryness and HIV disease in a national sample of patients receiving medical care. | |
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MedLine Citation:
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PMID: 11740480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We sought to analyze the relationship between self-reported oral dryness and the demographic, enabling, behavioral, clinical, and treatment characteristics among human immunodeficiency virus (HIV)-positive patients in medical care. Study Design: The study group consisted of the HIV Cost and Services Utilization Study cohort, a nationally representative probability sample of HIV-infected adults receiving medical care in the contiguous United States. RESULTS: It was estimated that 29% of adults (64,947 individuals) with HIV infection receiving medical care in the United States have a complaint of dry mouth. A multivariate logistic analysis was carried out to explore the association between several covariates and dry mouth. It was shown that compared with whites, individuals of Hispanic ethnic origin were 61% more likely to report dry mouth (OR, 1.61; 95% CI, 1.04-2.50; P =.04). Those who were unemployed were 55% more likely to report the symptom of dry mouth than were subjects who were employed (OR, 1.55; 95% CI, 1.22-1.98; P =.001). In comparison with nonsmokers, current smokers were 36% more likely to report dry mouth (OR, 1.36; 95% CI, 1.04-1.79;P =.03). The use of antidepressant drugs and antituberculosis/anti-Mycobacterium avium (anti-TB/anti-MAC) medications had the strongest association with dry mouth complaint. Those taking antidepressants were 55% more likely to report dry mouth (OR, 1.55; 95% CI, 1.23-1.97; P =.0001); compared with nonusers, patients receiving anti-TB/MAC drugs were 46% more likely to report dry mouth (OR, 1.46; 95% CI, 1.03-2.06; P =.04]. In comparison with those with undetectable viral load, individuals with a viral load of more than 100,000/mm(3) were 151% more likely to report dry mouth (OR, 2.51; 95% CI,1.58-3.96; P =.0001). CONCLUSIONS: Our findings suggest that optimizing viral suppression, smoking cessation, and tailoring antidepressant and anti-TB/MAC medications may be promising interventions to decrease dry-mouth symptoms among HIV-infected individuals. |
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Authors:
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F S Younai; M Marcus; J R Freed; I D Coulter; W Cunningham; C Der-Martirosian; N Guzman-Bercerra; M Shapiro |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics Volume: 92 ISSN: 1079-2104 ISO Abbreviation: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Publication Date: 2001 Dec |
Date Detail:
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Created Date: 2001-12-12 Completed Date: 2002-03-04 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 9508562 Medline TA: Oral Surg Oral Med Oral Pathol Oral Radiol Endod Country: United States |
Other Details:
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Languages: eng Pagination: 629-36 Citation Subset: D; IM |
Affiliation:
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Section of Oral Biology and Medicine, School of Dentistry, University of California, Los Angeles 90095-1668, USA. faribay@dent.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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adverse effects Adolescent Adult Analysis of Variance Antidepressive Agents / adverse effects Antitubercular Agents / adverse effects CD4-CD8 Ratio Cohort Studies Female HIV Infections / complications*, drug therapy Hispanic Americans / statistics & numerical data Humans Logistic Models Male Middle Aged Odds Ratio Self Assessment (Psychology) Smoking United States / epidemiology Viral Load Xerostomia / epidemiology, etiology* |
| Grant Support | |
ID/Acronym/Agency:
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HS08578/HS/AHRQ HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Antidepressive Agents; 0/Antitubercular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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