Document Detail

Self-reported snoring and risk of cardiovascular disease among postmenopausal women (from the Women's Health Initiative).
MedLine Citation:
PMID:  23219175     Owner:  NLM     Status:  MEDLINE    
Habitual snoring may be associated with cardiovascular disease (CVD); however, limited evidence exists among women. We investigated whether frequent snoring is a predictor of coronary heart disease (CHD) and stroke among 42,244 postmenopausal women participating in the Women's Health Initiative Observational Study. Participants provided self-reported information regarding snoring habits at baseline (1993 to 1998) and were followed up for outcomes through August 2009. Physician adjudicators confirmed CHD (defined as myocardial infarction, CHD death, revascularization procedures, or hospitalized angina) and ischemic stroke. Cox proportional hazards models were used to evaluate whether snoring frequency is a significant predictor of the adjudicated outcomes. We observed 2,401 incident cases of CHD during 437,899 person-years of follow-up. After adjusting for age and race, frequent snoring was associated with incident CHD (hazard ratio [HR] 1.54, 95% confidence interval [CI] 1.39 to 1.70) and stroke (HR 1.41, 95% CI 1.19 to 1.66), and all CVD (HR 1.46, 95% CI 1.34 to 1.60). In fully adjusted models that included CVD risk factors such as obesity, hypertension, and diabetes, frequent snoring was associated with a more modest increase in incident CHD (HR 1.14, 95% CI 1.01 to 1.28), stroke (HR 1.19, 95% CI 1.02 to 1.40), and CVD (HR 1.12, 95% CI 1.01 to 1.24). In conclusion, snoring is associated with a modest increased risk of incident CHD, stroke, and CVD after adjustment for CVD risk factors. Additional studies are needed to elucidate the mechanisms by which snoring might be associated with CVD risk factors and outcomes.
Megan Sands; Eric B Loucks; Bing Lu; Mary A Carskadon; Katherine Sharkey; Marcia Stefanick; Judith Ockene; Neomi Shah; Kristen G Hairston; Jennifer Robinson; Marian Limacher; Lauren Hale; Charles B Eaton
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.     Date:  2012-12-04
Journal Detail:
Title:  The American journal of cardiology     Volume:  111     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-04     Completed Date:  2013-04-15     Revised Date:  2014-10-07    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  540-6     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Cardiovascular Diseases / epidemiology*,  etiology
Middle Aged
Proportional Hazards Models
Risk Assessment / methods*
Risk Factors
Self Report*
Snoring / complications*,  epidemiology
United States / epidemiology
Women's Health*
Grant Support
HHSN268201100001C/WH/WHI NIH HHS; HHSN268201100001C//PHS HHS; HHSN268201100002C/WH/WHI NIH HHS; HHSN268201100002C//PHS HHS; HHSN268201100003C/WH/WHI NIH HHS; HHSN268201100003C//PHS HHS; HHSN268201100004C/WH/WHI NIH HHS; HHSN268201100004C//PHS HHS; HHSN268201100046C/HL/NHLBI NIH HHS; HHSN268201100046C//PHS HHS; HHSN271201100004C/AG/NIA NIH HHS; HHSN271201100004C//PHS HHS; R24 HD041020/HD/NICHD NIH HHS

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