Document Detail


Self-recognition and the role of fetal microchimerism.
MedLine Citation:
PMID:  15157836     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The course and severity of the autoimmune thyroid diseases (AITD) is known to be influenced by pregnancy as evidenced by disease suppression during pregnancy and initiation, or exacerbation, of disease postpartum. AITD is also known to affect both fertility and pregnancy outcome as evidenced by increased fetal loss. However, the precise mechanisms of this influence have not been fully understood. Here we have reviewed the mechanisms of self-recognition thought to be active in AITD and we have included recent information on the potential role of fetal microchimerism (exposure of paternal antigen to the mother during and after pregnancy).
Authors:
Takao Ando; Terry F Davies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  18     ISSN:  1521-690X     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-05-25     Completed Date:  2004-12-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  England    
Other Details:
Languages:  eng     Pagination:  197-211     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Diabetes, and Bone Diseases, Department of Medicine, Mount Sinai School of Medicine, Box 1055, 1 Gustave L. Levy Place, New York, NY 10029, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity / immunology*
Chimerism*
Female
Humans
Immune Tolerance / immunology*
Pregnancy
Pregnancy Complications / immunology*
Thyroiditis, Autoimmune / immunology*
Grant Support
ID/Acronym/Agency:
AI24671/AI/NIAID NIH HHS; DK45011/DK/NIDDK NIH HHS; DK52464/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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