Document Detail

Self-organized cell motility from motor-filament interactions.
MedLine Citation:
PMID:  22768929     Owner:  NLM     Status:  MEDLINE    
Cell motility is driven primarily by the dynamics of the cell cytoskeleton, a system of filamentous proteins and molecular motors. It has been proposed that cell motility is a self-organized process, that is, local short-range interactions determine much of the dynamics that are required for the whole-cell organization that leads to polarization and directional motion. Here we present a mesoscopic mean-field description of filaments, motors, and cell boundaries. This description gives rise to a dynamical system that exhibits multiple self-organized states. We discuss several qualitative aspects of the asymptotic states and compare them with those of living cells.
XinXin Du; Konstantin Doubrovinski; Miriam Osterfield
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Biophysical journal     Volume:  102     ISSN:  1542-0086     ISO Abbreviation:  Biophys. J.     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-07-09     Completed Date:  2012-10-09     Revised Date:  2013-07-12    
Medline Journal Info:
Nlm Unique ID:  0370626     Medline TA:  Biophys J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1738-45     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Biophysical Society. Published by Elsevier Inc. All rights reserved.
Physics Department, Princeton University, Princeton, New Jersey, USA.
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MeSH Terms
Actomyosin / metabolism
Cell Membrane / metabolism
Cell Movement*
Cytoskeleton / metabolism*
Models, Biological*
Molecular Motor Proteins / metabolism*
Protein Binding
Reg. No./Substance:
0/Molecular Motor Proteins; 9013-26-7/Actomyosin

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