Document Detail

Self-noise-filtering phase-sensitive surface plasmon resonance biosensing.
MedLine Citation:
PMID:  20639919     Owner:  NLM     Status:  MEDLINE    
Emerged as an upgrade of currently available Surface Plasmon Resonance (SPR) biosensing in terms of sensitivity, phase-sensitive SPR technology still requires the minimization of instrumental noises to profit from its projected ultra-low detection limit (10(-8) refractive index units and lower). We present a polarimetry-based methodology for the efficient reduction of main instrumental noises in phase-sensitive measurements. The proposed approach employs a sinusoidal phase modulation of pumping light and is based on selection of proper modulation amplitude and initial phase relation for the first two modulation harmonics (F1 and F2), which enables to subtract amplitude drifts in the difference (F1 - F2) signal while doubling the phase response. The resulting effect can be called self-noise-filtering, since it implies an inherent noise subtraction in every phase sensing measurement. This methodology allows one to tackle drifts related to instabilities of light sources and optical elements and thus drastically lower the detection limit of phase-sensitive SPR sensing even in relatively simple and noisy experimental implementations.
Sergiy Patskovsky; Michel Meunier; Paras N Prasad; Andrei V Kabashin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Optics express     Volume:  18     ISSN:  1094-4087     ISO Abbreviation:  Opt Express     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-07-19     Completed Date:  2010-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137103     Medline TA:  Opt Express     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14353-8     Citation Subset:  IM    
Department of Engineering Physics, Ecole Polytechnique de Montréal, Case Postale 6079, succ. Centre-Ville, Montréal, Québec, H3C 3A7 Canada.
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MeSH Terms
Biosensing Techniques / methods*
Nitrogen / analysis
Surface Plasmon Resonance / methods*
Reg. No./Substance:

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