Document Detail

Self-healing congenital Langerhans cell histiocytosis presenting as neonatal papulovesicular eruption.
MedLine Citation:
PMID:  11907857     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare condition which may present at birth or during the neonatal period. It is usually characterized by the eruption of multiple, disseminated, red-brown papules and nodules which may increase in size and number during the first few weeks of life. Systemic signs are usually absent except for occasional mild hepatomegaly. OBJECTIVE: We present a 3.5-kg male infant who presented at birth with numerous diffuse, erythematous, crusted erosions. He was presumed to have congenital herpes simplex virus (HSV) and was started on IV acyclovir. Histopathologic examination revealed a mixed inflammatory infiltrate with numerous histiocytes which were S-100 and peanut agglutin positive consistent with CSHLCH. Further workup did not reveal any signs of systemic involvement. CONCLUSION: CSHLCH has rarely been reported to present as a papulovesicular eruption at birth. In these cases, a viral etiology is commonly entertained in the differential diagnosis. Despite the spontaneous regression of skin lesions in CSHLCH, close followup is required to evaluate for systemic signs and symptoms associated with latent Letterer-Siwe disease.
K W Morgan; J P Callen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cutaneous medicine and surgery     Volume:  5     ISSN:  1203-4754     ISO Abbreviation:  J Cutan Med Surg     Publication Date:    2001 Nov-Dec
Date Detail:
Created Date:  2002-03-21     Completed Date:  2002-10-21     Revised Date:  2007-07-04    
Medline Journal Info:
Nlm Unique ID:  9614685     Medline TA:  J Cutan Med Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  486-9     Citation Subset:  IM    
Department of Medicine, Division of Dermatology, University of Louisville, 310 East Broadway Avenue, Louisville, KY 40202, USA.
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MeSH Terms
Histiocytosis, Langerhans-Cell* / complications,  pathology
Infant, Newborn
Remission, Spontaneous
Skin Diseases, Vesiculobullous* / etiology,  pathology

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