| Self-expandable and highly flexible nitinol stent: immediate and long-term results in dogs. | |
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MedLine Citation:
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PMID: 7942477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We sought to investigate the acute and long-term patency rates and the histologic response of coronary arteries to a self-expandable nitinol coil stent. Twenty-two stents were implanted. Angiographic patency was demonstrated acutely in all but one dog, in which the stent was released in a small branch (1 mm); mismatch in stent-to-artery diameters resulted in vessel closure. Two dogs died from anesthesia overdose and two from bleeding within 24 hours. All dogs were treated with aspirin (80 mg/day) and warfarin (2.5 mg/day) for up to 1 month. Sixteen dogs were monitored for 1 to 2 weeks, 1 month, 3 months, 6 months, and 1 year and underwent subsequent angiography and histopathologic examination. Angiographic artery dimensions measured immediately after stent implantation (2.72 +/- 0.4 mm) did not differ from those noted at follow-up (2.68 +/- 0.44 mm, p not significant). Histologic examination showed outward stent pressure compressing the internal elastic membrane and media in most cases. Intimal hyperplasia started at 2 weeks and was most apparent at 3 and 6 months. Mean intimal thickness was 30.7 +/- 10.9 mu, 141.8 +/- 105.4 mu, 227.1 +/- 104.1 mu, 211.8 +/- 99.1 mu, and 170.1 +/- 42.7 mu at 1 to 2 weeks and 1, 3, 6 and 12 months, respectively. Therefore the nitinol self-expandable stent provokes a moderate cellular proliferative response that reaches its maximum in 3 to 6 months without further progression. |
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Authors:
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E Grenadier; R Shofti; M Beyar; H Lichtig; D Mordechowitz; O Globerman; W Markiewicz; R Beyar |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: American heart journal Volume: 128 ISSN: 0002-8703 ISO Abbreviation: Am. Heart J. Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-11-18 Completed Date: 1994-11-18 Revised Date: 2006-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 870-8 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Rambam Medical Center, Haifa, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alloys* Animals Coronary Angiography Coronary Vessels* / pathology, physiology Dogs Equipment Design Hyperplasia / pathology Stents* Time Factors Tunica Intima / pathology Vascular Patency / physiology |
| Chemical | |
Reg. No./Substance:
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0/Alloys; 52013-44-2/nitinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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