Document Detail

Self-control of level of mechanical ventilation to minimize CO2 induced air hunger.
MedLine Citation:
PMID:  8833543     Owner:  NLM     Status:  MEDLINE    
Hypercapnia produces an uncomfortable urge to breathe ('air hunger'), which is alleviated by increasing breathing. It has been postulated that awake humans control breathing partly to minimize these sensations; such behavioral control presumably involves the forebrain. To test this postulate, we compared the ventilatory response to hypercapnia when the subject breathed spontaneously to the response when the subject used forebrain commands to control ventilation--on the basis of minimizing air hunger (achieved with subject-controlled positive pressure ventilation). In six healthy adults during hypercapnia (46 mmHg), spontaneous ventilation significantly exceeded, by 17%, the level of (mechanical) ventilation needed to alleviate air hunger. This suggests that spontaneous breathing is not behaviorally controlled to minimize discomfort. Alternatively, mechanical ventilation confers an additional relief of air hunger beyond that provided by spontaneous breathing. Since mechanical ventilation (with reduced respiratory muscle contraction) was more effective than spontaneous breathing in relieving air hunger, our results also suggest afferents that signal the degree of respiratory muscle contraction do not contribute to air hunger relief.
S A Shea; H R Harty; R B Banzett
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Respiration physiology     Volume:  103     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1997-06-05     Completed Date:  1997-06-05     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  113-25     Citation Subset:  IM; S    
Physiology Program, Harvard School of Public Health, Boston, MA 02115, USA.
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MeSH Terms
Carbon Dioxide / physiology*
Hypercapnia / physiopathology*
Pulmonary Ventilation / physiology*
Grant Support
HL-46690/HL/NHLBI NIH HHS; //Wellcome Trust
Reg. No./Substance:
124-38-9/Carbon Dioxide

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