Document Detail

Self-association of arrestin family members.
MedLine Citation:
PMID:  24292832     Owner:  NLM     Status:  MEDLINE    
Mammals express four arrestin subtypes, three of which have been shown to self-associate. Cone photoreceptor-specific arrestin-4 is the only one that is a constitutive monomer. Visual arrestin-1 forms tetramers both in crystal and in solution, but the shape of its physiologically relevant solution tetramer is very different from that in the crystal. The biological role of the self-association of arrestin-1, expressed at very high levels in rod and cone photoreceptors, appears to be protective, reducing the concentration of cytotoxic monomers. The two nonvisual arrestin subtypes are highly homologous, and self-association of both is facilitated by IP6, yet they form dramatically different oligomers. Arrestin-2 apparently self-associates into "infinite" chains, very similar to those observed in IP6-soaked crystals, where IP6 connects the concave sides of the N- and C-domains of adjacent protomers. In contrast, arrestin-3 only forms dimers, in which IP6 likely connects the C-domains of two arrestin-3 molecules. Thus, each of the three self-associating arrestins does it in its own way, forming three different types of oligomers. The physiological role of the oligomerization of arrestin-1 and both nonvisual arrestins might be quite different, and in each case it remains to be definitively elucidated.
Qiuyan Chen; Ya Zhuo; Miyeon Kim; Susan M Hanson; Derek J Francis; Sergey A Vishnivetskiy; Christian Altenbach; Candice S Klug; Wayne L Hubbell; Vsevolod V Gurevich
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Handbook of experimental pharmacology     Volume:  219     ISSN:  0171-2004     ISO Abbreviation:  Handb Exp Pharmacol     Publication Date:  2014  
Date Detail:
Created Date:  2013-12-02     Completed Date:  2014-04-18     Revised Date:  2014-06-12    
Medline Journal Info:
Nlm Unique ID:  7902231     Medline TA:  Handb Exp Pharmacol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  205-23     Citation Subset:  IM    
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MeSH Terms
Arrestins / metabolism*
Phytic Acid / metabolism
Protein Multimerization
Retinal Cone Photoreceptor Cells / metabolism*
Retinal Rod Photoreceptor Cells / metabolism*
Grant Support
P30 EY000331/EY/NEI NIH HHS; R01 EY005216/EY/NEI NIH HHS
Reg. No./Substance:
0/Arrestins; 7IGF0S7R8I/Phytic Acid

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