| Self-assembly of SiO2/Gd-DTPA-polyethylenimine nanocomposites as magnetic resonance imaging probes. | |
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MedLine Citation:
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PMID: 20352889 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Controlled self-assembly of organic/inorganic magnetic hybrid materials have important applications in magnetic resonance imaging (MRI). In this study, a widely used polycation polyethylenimine was conjugated with gadopentetic acid (Gd-DTPA) as a gadolinium bearing polyelectrolyte (Gd-DTPA-PEI). Next, multilayers of Gd-DTPA-PEI were coated on silica nanoparticles through layer-by-layer (LbL) self-assembly with polyanions as monitored by dynamic light scattering, zeta-potential, and scanning electron microscopy. The thickness of the multilayer film was estimated from quartz crystal microbalance based on counting frequency change of each adsorbed layer. The magnetic relaxation of SiO2/(Gd-DTPA-PEl/polyanion), core-shell nanocomposite was tested at 1.5 T magnetic field in a clinical MRI scanner, and a 3-fold increase in T1 relaxivity to 15.1 Gd mM(-1)s(-1) was noticed comparing to Gd-DTPA small molecules. Dextran sulfate was coated as the outermost layer on the nanocomposite for better biocompatibility as verified by in vitro cytotoxicity studies. This formulation provides good signal intensity enhancement of mouse liver in vivo with only 1/25 dose of clinical standard at 30 and 60 minutes after intravenous injection. This sensitive imaging probe with unique core-shell structures may find broad applications in cellular and molecular imaging. |
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Authors:
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Kui Luo; Jing Tian; Gang Liu; Jiayu Sun; Chunchao Xia; Hehan Tang; Ling Lin; Tianxin Miao; Xuna Zhao; Fabao Gao; Qiyong Gong; Bin Song; Xintao Shuai; Hua Ai; Zhongwei Gu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of nanoscience and nanotechnology Volume: 10 ISSN: 1533-4880 ISO Abbreviation: J Nanosci Nanotechnol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-03-31 Completed Date: 2010-05-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101088195 Medline TA: J Nanosci Nanotechnol Country: United States |
Other Details:
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Languages: eng Pagination: 540-8 Citation Subset: IM |
Affiliation:
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National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry, pharmacology Cell Line, Tumor Cell Survival Gadolinium DTPA / analogs & derivatives*, chemistry, pharmacology Humans Imines / chemistry*, pharmacology Liver / drug effects, metabolism Magnetic Resonance Imaging / methods* Materials Testing Mice Nanocomposites / administration & dosage, chemistry* Nanotechnology / methods Polyethylenes / chemistry*, pharmacology Polymers / chemistry, pharmacology Silicon Dioxide / chemistry*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/Imines; 0/Polyethylenes; 0/Polymers; 0/poly(ethylene imine); 0/polyanions; 7631-86-9/Silicon Dioxide; 80529-93-7/Gadolinium DTPA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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