Document Detail


Self-assembling peptides: from bio-inspired materials to bone regeneration.
MedLine Citation:
PMID:  18573978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In recent years, the development of new biomaterials with specifications for tissue and organ functional requirements-such as proper biological, structural, and biomechanical properties as well as designed control for biodegradation and therapeutic drug-release capacity-is the main aim of many academic and industrial programs. Hence, the concept of molecular self-assembly is the driving force for the development of new biomaterials that support the growth and functional differentiation of cells and tissues in a controlled manner. The discovery, properties, and development of self-assembling peptides to be used as three-dimensional (3D) scaffolds based on their similarity (in structure and mechanical features) to extracellular matrices are described. Self-assembling peptides can be used for in vitro applications for cell 3D culture as well as in vivo for tissue regeneration such as bone and optical nerve repair, as well as for drug delivery of mediators to improve therapy, as in the case of myocardial infarction. Finally, the use of self-assembling materials in combination with a bioengineering platform is proposed to assist functional bone regeneration in cases of larger bone defects, including exposed fractures due to trauma and spinal disorders dealing with high loadings, as well as replacement of big bone structures due to tumors.
Authors:
C E Semino
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of dental research     Volume:  87     ISSN:  0022-0345     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  606-16     Citation Subset:  D; IM    
Affiliation:
Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. semino@mit.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemical synthesis*
Bone Regeneration*
Humans
Molecular Conformation
Nanostructures / chemistry
Peptides / chemistry*
Protein Engineering / methods*
Protein Subunits / chemistry
Regenerative Medicine / methods*
Tissue Scaffolds
Grant Support
ID/Acronym/Agency:
1-R01-EB003805-01A1/EB/NIBIB NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Peptides; 0/Protein Subunits

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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