| Self-assembling nanoclusters in living systems: application for integrated photothermal nanodiagnostics and nanotherapy. | |
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MedLine Citation:
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PMID: 17292107 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nanotechnologies represent an unprecedented recent advance that may revolutionize many areas of medicine and biology, including cancer diagnostics and treatment. Nanoparticle-based technologies have demonstrated especially high potential for medical purposes, ranging from diagnosing diseases to providing novel therapies. However, to be clinically relevant, the existing nanoparticle-based technologies must overcome several challenges, including selective nanoparticle delivery, potential cytotoxicity, imaging of nanoparticles, and real-time assessment of their therapeutic efficacy. This review addresses these issues by summarizing the recent advances in medical diagnostics and therapy with a focus on the self-assembly of gold nanoparticles into nanoclusters in live cells, in combination with their detection using photothermal (PT) techniques. |
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Authors:
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Vladimir P Zharov; Jin-Woo Kim; David T Curiel; Maaike Everts |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Nanomedicine : nanotechnology, biology, and medicine Volume: 1 ISSN: 1549-9642 ISO Abbreviation: - Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2007-02-12 Completed Date: 2007-03-05 Revised Date: 2007-12-03 |
Medline Journal Info:
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Nlm Unique ID: 101233142 Medline TA: Nanomedicine Country: United States |
Other Details:
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Languages: eng Pagination: 326-45 Citation Subset: IM |
Affiliation:
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Philips Classic Laser Laboratories, the Arkansas Cancer Research Center, the University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. zharovvladimirp@uams.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Contrast Media* Diagnostic Imaging / methods*, trends Drug Delivery Systems / methods*, trends Nanomedicine / methods*, trends Nanostructures / diagnostic use*, therapeutic use* Phototherapy / methods*, trends |
| Grant Support | |
ID/Acronym/Agency:
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EB001858/EB/NIBIB NIH HHS; R01 EB000873/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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