Document Detail


Self-assembled nanoparticles of modified-chitosan conjugates for the sustained release of dl-α-tocopherol.
MedLine Citation:
PMID:  23218376     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Synthetic O6-succinylated chitosan and commercial glycol chitosan were covalently linked to dl-α-tocopheryl monoesters for controlled release of vitamin E. These conjugates formed self-assembled nanoparticles in aqueous solution with 254-496nm mean diameters and dl-α-tocopherol contents between 27 and 39% (w/w). The particles appeared as 40-75nm almost spherical nanoparticles when studied by scanning and transmission electron microscopy upon drying. Drug linking to chitosan matrix was confirmed by FTIR spectroscopy and proton NMR. Conjugates were also characterized by differential scanning calorimetry and wide-angle X-ray diffraction. In vitro tocopherol release studies performed in water at acid pH indicated a drug release dependence on drug content, hydrated particle sizes and employed chitosan derivative. Almost constant release rates were observed the first 7h. The obtained nanoparticles exhibited radical scavenging activity in DPPH essay. The potential of these nanoparticles was also demonstrated by the enhancement of HMVEC cell proliferation.
Authors:
Javier Pérez Quiñones; Kurt Vesterager Gothelf; Jørgen Kjems; Chuanxu Yang; Angeles María Heras Caballero; Claudia Schmidt; Carlos Peniche Covas
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Publication Detail:
Type:  Journal Article     Date:  2012-10-13
Journal Detail:
Title:  Carbohydrate polymers     Volume:  92     ISSN:  1879-1344     ISO Abbreviation:  Carbohydr Polym     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8307156     Medline TA:  Carbohydr Polym     Country:  England    
Other Details:
Languages:  eng     Pagination:  856-64     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Center of Natural Products, Faculty of Chemistry, University of Havana, Havana, Cuba. Electronic address: javierp@fq.uh.cu.
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