Document Detail


Self-assembled lipid--polymer hybrid nanoparticles: a robust drug delivery platform.
MedLine Citation:
PMID:  19206374     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the engineering of a novel lipid-polymer hybrid nanoparticle (NP) as a robust drug delivery platform, with high drug encapsulation yield, tunable and sustained drug release profile, excellent serum stability, and potential for differential targeting of cells or tissues. The NP comprises three distinct functional components: (i) a hydrophobic polymeric core where poorly water-soluble drugs can be encapsulated; (ii) a hydrophilic polymeric shell with antibiofouling properties to enhance NP stability and systemic circulation half-life; and (iii) a lipid monolayer at the interface of the core and the shell that acts as a molecular fence to promote drug retention inside the polymeric core, thereby enhancing drug encapsulation efficiency, increasing drug loading yield, and controlling drug release. The NP is prepared by self-assembly through a single-step nanoprecipitation method in a reproducible and predictable manner, making it potentially suitable for scale-up.
Authors:
Liangfang Zhang; Juliana M Chan; Frank X Gu; June-Wha Rhee; Andrew Z Wang; Aleksandar F Radovic-Moreno; Frank Alexis; Robert Langer; Omid C Farokhzad
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  ACS nano     Volume:  2     ISSN:  1936-086X     ISO Abbreviation:  ACS Nano     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-03-20     Revised Date:  2014-10-02    
Medline Journal Info:
Nlm Unique ID:  101313589     Medline TA:  ACS Nano     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1696-702     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Crystallization / methods
Diffusion
Drug Carriers / chemistry*
Drug Design*
Hydrophobic and Hydrophilic Interactions
Lipids / chemistry*
Macromolecular Substances / chemistry
Materials Testing
Molecular Conformation
Nanomedicine / methods
Nanostructures / chemistry*,  ultrastructure*
Particle Size
Pharmaceutical Preparations / administration & dosage,  chemistry*
Polymers / chemistry*
Solubility
Surface Properties
Grant Support
ID/Acronym/Agency:
CA119349/CA/NCI NIH HHS; EB003647/EB/NIBIB NIH HHS; U54 CA119349/CA/NCI NIH HHS; U54 CA151884/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Drug Carriers; 0/Lipids; 0/Macromolecular Substances; 0/Pharmaceutical Preparations; 0/Polymers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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