| Self-aggregates of oligoarginine-conjugated poly(amino acid) derivatives as a carrier for intracellular drug delivery. | |
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MedLine Citation:
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PMID: 16132840 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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N(omega)-2,2,4,6,7-Pentamethyldihydrobenzofuran-5-sulfonyl (N(omega)-Pbf)-protected oligoarginine was directly conjugated to poly(amino acid) derivatives modified with a long alkyl chain. The final concentration of conjugated peptides was easily controlled by the feed ratio of oligoarginine to polymer backbone and a final soluble polymeric system was obtained by the deprotection of N(omega)-Pbf groups. The polymeric conjugates formed stable self-aggregates of size range of 8-40 nm in aqueous solution and effectively internalized into HeLa cells by adsorptive endocytosis. |
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Authors:
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Seung Rim Yang; Seung Beom Kim; Cheol O Joe; Jong-Duk Kim |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biotechnology letters Volume: 27 ISSN: 0141-5492 ISO Abbreviation: Biotechnol. Lett. Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-08-31 Completed Date: 2006-02-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8008051 Medline TA: Biotechnol Lett Country: Netherlands |
Other Details:
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Languages: eng Pagination: 977-82 Citation Subset: IM |
Affiliation:
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Department of Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, 305-701, Guseong-dong, Yuseong-gu, Daejeon, Republic of Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Drug Delivery Systems* Endocytosis* / drug effects Hela Cells Humans Peptides / chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Peptides; 25212-18-4/polyarginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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