Document Detail

Self-administration of phenylpropanolamine (PPA) by rats previously trained to self-administer amphetamine.
MedLine Citation:
PMID:  2626448     Owner:  NLM     Status:  MEDLINE    
Central nervous system stimulation, similar to that observed for amphetamine, has been attributed to phenylpropanolamine (PPA). However, formal tests, using evaluation of locomotion or of self-administration, fail to reveal that PPA is a stimulant. Self-administration studies have trained rats to self-administer cocaine and then have attempted to switch rats to PPA with no success of transfer. The present study further examined the reinforcing properties of PPA (0.08, 0.16, and 0.32 mg/infusion, IV) in rats that were initially trained to self-administer d-amphetamine (0.005-0.08 mg/infusion) in a two-lever paradigm. Self-administration of amphetamine was a function of dose with 0.01 mg/infusion producing reliably high responding on the active lever. The proportion of active/inactive lever presses remained constant (0.60-0.80) across the amphetamine dose range. PPA was dose-dependently self-administered during the first hour of each session with rats responding at approximately 70% on the active lever. In contrast, responding on the active lever dropped off to approximately 48% when saline was substituted for amphetamine. These data document that rats with prior exposure to amphetamine will self-administer PPA during the initial portion of a three-hour test.
P J Wellman; K Shelton; S Schenk
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  34     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1990-04-03     Completed Date:  1990-04-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-91     Citation Subset:  IM    
Department of Psychology, Texas A&M University, College Station 77843.
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MeSH Terms
Amphetamine / administration & dosage*
Dose-Response Relationship, Drug
Generalization, Stimulus*
Phenylpropanolamine / administration & dosage*,  pharmacology
Rats, Inbred Strains
Reinforcement (Psychology)*
Self Administration
Time Factors
Reg. No./Substance:
14838-15-4/Phenylpropanolamine; 300-62-9/Amphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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