Document Detail


Self-administration of delta 9-tetrahydrocannabinol by rats.
MedLine Citation:
PMID:  231789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study examines the dose-response pattern of delta 9-tetrahydrocannabinol self-injection in naive rats at 80% reduced body weight and 100% body weight, both conditions with a fixed-time 1 min (FT-1) food delivery schedule. The results indicated that food deprived animals tested on a FT-1 min schedule self-injected low doses of delta 9-THC at a higher rate than those animals at 100% body weight and on a FT-1 min schedule. Animals at 80% reduced body weight without a schedule did not differ from rats self-injecting delta 9-THC at free feeding situation. These findings suggest that rats without previous history of drug dependence self-administer low doses of delta 9-THC and that the interaction between the food deprivation state and the environmental contingencies introduced by a FT-1 min schedule is a critical variable in the acquisition period.
Authors:
R N Takahashi; G Singer
Related Documents :
19748839 - The growth of obesity and technological change.
6611699 - Energetic limits on reproduction: maternal food intake.
2766099 - Effects of rearing temperature and level of food intake on organ size and tissue compos...
7217159 - Unsuspected esophageal foreign bodies.
817609 - Feeding behavior in monkeys with and without lesions of the hypothalamus.
6434709 - The effect of amino acid excess on utilization by the rat of the limiting amino acid--l...
17332269 - Hypoxic stimulus alters hypothalamic amp-activated protein kinase phosphorylation conco...
16261809 - Seafood allergy: lessons from clinical symptoms, immunological mechanisms and molecular...
18199019 - Nutritional and environmental approaches to preventing and treating autism and attentio...
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Pharmacology, biochemistry, and behavior     Volume:  11     ISSN:  0091-3057     ISO Abbreviation:  Pharmacol. Biochem. Behav.     Publication Date:  1979 Dec 
Date Detail:
Created Date:  1980-05-30     Completed Date:  1980-05-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0367050     Medline TA:  Pharmacol Biochem Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  737-40     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Conditioning, Operant / drug effects
Male
Rats
Reinforcement Schedule
Self Administration
Tetrahydrocannabinol / administration & dosage*,  pharmacology
Chemical
Reg. No./Substance:
1972-08-3/Tetrahydrocannabinol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Processing of common precursor forms of adrenocorticotropin and endorphins in cultures of mouse pitu...
Next Document:  Effect of autoanalgesia on CNS enkephalin receptors.