| Self-administration of delta 9-tetrahydrocannabinol by rats. | |
| | |
MedLine Citation:
|
PMID: 231789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study examines the dose-response pattern of delta 9-tetrahydrocannabinol self-injection in naive rats at 80% reduced body weight and 100% body weight, both conditions with a fixed-time 1 min (FT-1) food delivery schedule. The results indicated that food deprived animals tested on a FT-1 min schedule self-injected low doses of delta 9-THC at a higher rate than those animals at 100% body weight and on a FT-1 min schedule. Animals at 80% reduced body weight without a schedule did not differ from rats self-injecting delta 9-THC at free feeding situation. These findings suggest that rats without previous history of drug dependence self-administer low doses of delta 9-THC and that the interaction between the food deprivation state and the environmental contingencies introduced by a FT-1 min schedule is a critical variable in the acquisition period. |
| | |
Authors:
|
R N Takahashi; G Singer |
Related Documents
:
|
19748839 - The growth of obesity and technological change. 6611699 - Energetic limits on reproduction: maternal food intake. 2766099 - Effects of rearing temperature and level of food intake on organ size and tissue compos... 7217159 - Unsuspected esophageal foreign bodies. 817609 - Feeding behavior in monkeys with and without lesions of the hypothalamus. 6434709 - The effect of amino acid excess on utilization by the rat of the limiting amino acid--l... 17332269 - Hypoxic stimulus alters hypothalamic amp-activated protein kinase phosphorylation conco... 16261809 - Seafood allergy: lessons from clinical symptoms, immunological mechanisms and molecular... 18199019 - Nutritional and environmental approaches to preventing and treating autism and attentio... |
Publication Detail:
|
Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: Pharmacology, biochemistry, and behavior Volume: 11 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1979 Dec |
Date Detail:
|
Created Date: 1980-05-30 Completed Date: 1980-05-30 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 737-40 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Conditioning, Operant / drug effects Male Rats Reinforcement Schedule Self Administration Tetrahydrocannabinol / administration & dosage*, pharmacology |
| Chemical | |
Reg. No./Substance:
|
1972-08-3/Tetrahydrocannabinol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Processing of common precursor forms of adrenocorticotropin and endorphins in cultures of mouse pitu...
Next Document: Effect of autoanalgesia on CNS enkephalin receptors.