| Self-administration of central stimulants by rats: a comparison of the effects of d-amphetamine, methylphenidate and McNeil 4612. | |
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MedLine Citation:
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PMID: 6144109 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Rats were trained to press a lever for the intravenous administration of d-amphetamine. The rate of responding was decreased in a dose-dependent and time-related manner by non-contingent injections of d-amphetamine, methylphenidate or McNeil 4612. Methylphenidate and McNeil 4612 also maintained self-administration behavior when they were substituted for d-amphetamine, whereas substitution of saline for d-amphetamine resulted in extinction of the self-administration behavior. These data suggest that methylphenidate and McNeil 4612, like d-amphetamine, can act as reinforcers in rats. |
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Authors:
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J A Nielsen; N J Duda; D J Mokler; K E Moore |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Pharmacology, biochemistry, and behavior Volume: 20 ISSN: 0091-3057 ISO Abbreviation: Pharmacol. Biochem. Behav. Publication Date: 1984 Feb |
Date Detail:
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Created Date: 1984-06-05 Completed Date: 1984-06-05 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0367050 Medline TA: Pharmacol Biochem Behav Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 227-32 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Central Nervous System Stimulants / pharmacology* Dextroamphetamine / pharmacology Dose-Response Relationship, Drug Injections, Intravenous Isoquinolines / pharmacology* Male Methylphenidate / pharmacology Rats Rats, Inbred Strains Self Administration |
| Grant Support | |
ID/Acronym/Agency:
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15911//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 0/Isoquinolines; 113-45-1/Methylphenidate; 51-64-9/Dextroamphetamine; 87519-84-4/McN 4612 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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