Document Detail

Selenomethionine biotransformation and incorporation into proteins along a simulated terrestrial food chain.
MedLine Citation:
PMID:  17547184     Owner:  NLM     Status:  MEDLINE    
Selenium is an essential trace element in vertebrates, but there is a narrow concentration range between dietary requirement and toxicity threshold. Although a great deal is known about the biochemistry of Se from a nutritional perspective, considerably less attention has been focused on the specific biochemistry of Se as an environmental toxicant. Recent advances in hyphenated analytical techniques have provided the capability of quantifying specific chemical forms of Se in biological tissues as well as the distribution of Se among macromolecules. We applied liquid chromatography coupled to inductively coupled plasma mass spectrometryto investigate biotransformations of selenomethionine along a simulated terrestrial food chain consisting of selenomethionine exposed crickets (Acheta domesticus) fed to western fence lizards (Sceloporus occidentalis). Evidence was obtained for selenomethionine biotransformation as well as for sex-specific differences in the metabolism of Se compounds and their subsequent incorporation into proteins in the lizard. The results demonstrate the complexities involved in trophic transfer of Se due to the potential for extensive biotransformation and the species- and even sex-specific nature of these biotransformations.
Jason M Unrine; Brian P Jackson; William A Hopkins
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Environmental science & technology     Volume:  41     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-06-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3601-6     Citation Subset:  IM    
The University of Georgia, P.O. Drawer E, Aiken, South Carolina 29802, Departments of Chemistry and Earth Sciences, Dartmouth College, Hanover, New Hampshire, USA.
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MeSH Terms
Chromatography, Gel
Food Chain*
Insects / metabolism
Lizards / metabolism
Models, Biological*
Molecular Weight
Proteins / metabolism*
Selenium / analysis
Selenomethionine / metabolism*
Sulfur / analysis
Reg. No./Substance:
0/Proteins; 1464-42-2/Selenomethionine; 7704-34-9/Sulfur; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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