Document Detail

Selenoamino acids in tissues of rats administered inorganic selenium.
MedLine Citation:
PMID:  1250164     Owner:  NLM     Status:  MEDLINE    
There are conflicting reports in the literature concerning the synthesis of selenoamino acids from inorganic selenium in animals, and this work was undertaken to further investigate this. Pronase digests of acetone powders of liver and kidney tissue from rats administered 75SeO3= were subjected to fractionation by cation exchange chromatography using current methods for separating the various amino acids. Very little, if any, selenocystine was found in the digests. However, good evidence was obtained for the occurrence of 2,7-diamino-4-thia-5-selenaoctanedioic acid. It is suggested that the selenocysteine portion of this compound was formed by the reduction of the selenite to selenide with its subsequent incorporation into the amino acid by the action of serine hydrolase (E C No selenomethionine was found under the conditions of this study.
O E Olson; I S Palmer
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  25     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1976 Mar 
Date Detail:
Created Date:  1976-04-19     Completed Date:  1976-04-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  299-306     Citation Subset:  IM    
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MeSH Terms
Amino Acids, Sulfur / biosynthesis*
Cysteine / analogs & derivatives,  biosynthesis
Cystine / analogs & derivatives,  biosynthesis
Kidney / metabolism
Liver / metabolism
Selenium / pharmacology*
Reg. No./Substance:
0/Amino Acids, Sulfur; 0/Radioisotopes; 52-90-4/Cysteine; 56-89-3/Cystine; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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