Document Detail


Selenium-vitamin E supplementation in infertile men. Effects on semen parameters and micronutrient levels and distribution.
MedLine Citation:
PMID:  8862739     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In order to verify the hypothesis that selenium (Se) and vitamin E (Vit E) could improve male fertility, nine oligoasthenoteratozoospermic men were supplemented for a period of 6 mo with Se and Vit E. Compared to the baseline period (presupplementation) of 4 mo, statistically significant increases were observed for Se and Vit E levels, sperm motility, percent live, and percent normal spermatozoa. These improvements are likely to be "supplementation-dependent," since all of the parameters returned to baseline values during the posttreatment period. None of the couples reported a pregnancy during the study. The HPLC analysis conducted on the serum of one of the patients showed the existence of at least six different Se-containing peaks, whose Se content was affected by supplementation. The mechanism(s) involved in these improvements of semen parameters is presently under investigation.
Authors:
D Vézina; F Mauffette; K D Roberts; G Bleau
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  53     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  1996  
Date Detail:
Created Date:  1997-01-08     Completed Date:  1997-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  65-83     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of Montreal, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adult
Chromatography, High Pressure Liquid
Female
Glutathione Peroxidase / metabolism
Gonadal Steroid Hormones / blood
Humans
Infertility, Male / drug therapy,  physiopathology*
Male
Pregnancy
Selenium / blood,  pharmacology*,  therapeutic use
Semen* / enzymology
Sperm Count / drug effects
Sperm Motility / drug effects
Spermatozoa / drug effects,  physiology
Vitamin E / blood,  pharmacology*,  therapeutic use
Chemical
Reg. No./Substance:
0/Gonadal Steroid Hormones; 1406-18-4/Vitamin E; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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