Document Detail


Selenium treatment in autoimmune thyroiditis: 9-month follow-up with variable doses.
MedLine Citation:
PMID:  16837619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study is to investigate the long-term (9 months) effects of variable doses (200/100 microg/day) of L-selenomethionine on autoimmune thyroiditis (AIT) and the parameters affecting the success rate of this therapy. The present study was designed in three steps: (1) 88 female patients with AIT (mean age = 40.1 +/- 13.3 years) were randomized into two groups according to their initial serum TSH, thyroid peroxidase antibody (TPOAb) concentrations, and age. All the patients were receiving L-thyroxine to keep serum TSH <or=2 mIU/l. Group S2 (n = 48, mean TPOAb = 803.9 +/- 483.8 IU/ml) received 200 microg L-selenomethionine per day, orally for 3 months, and group C (n = 40, mean TPOAb = 770.3 +/- 406.2 IU/ml) received placebo. (2) 40 volunteers of group S2 were randomized into two age- and TPOAb-matched groups. Group S22 (n = 20) went on taking L-selenomethionine 200 microg/day, while others (group S21) lowered the dose to 100 microg/day. (3) 12 patients of group S22 (group S222) went on taking L-selenomethionine 200 microg/day, while 12 patients of group S21 (S212) increased the dose to 200 microg/day. Serum titers of TPOAb decreased significantly in group S2 (26.2%, P < 0.001), group S22 (23.7%, P < 0.01) and group S212 (30.3%, P < 0.01). There were no significant changes in group C and group S222 (P > 0.05). TPOAb titers increased significantly in group S21 (38.1%, P < 0.01). A significant decrease in thyroglobulin antibody titers was only noted in group S2 (5.2%, P < 0.01). L-selenomethionine substitution suppresses serum concentrations of TPOAb in patients with AIT, but suppression requires doses higher than 100 microg/day which is sufficient to maximize glutathione peroxidase activities. The suppression rate decreases with time.
Authors:
Omer Turker; Kamil Kumanlioglu; Inanc Karapolat; Ismail Dogan
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  190     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-13     Completed Date:  2006-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  151-6     Citation Subset:  IM    
Affiliation:
Thyroidology Unit, Department of Nuclear Medicine, GATA Haydarpasa, Istanbul, Turkey. otturker@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Analysis of Variance
Antibodies, Monoclonal / blood
Drug Administration Schedule
Female
Follow-Up Studies
Humans
Iodide Peroxidase / immunology
Male
Middle Aged
Selenium / administration & dosage*,  therapeutic use
Statistics, Nonparametric
Thyroiditis, Autoimmune / blood,  drug therapy*
Thyrotropin / blood
Thyroxine / blood
Triiodothyronine / blood
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 7782-49-2/Selenium; 9002-71-5/Thyrotropin; EC 1.11.1.8/Iodide Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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