Document Detail


Selenium supplementation and ischemia-reperfusion injury in rats.
MedLine Citation:
PMID:  15720825     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac ischemia--reperfusion injury results in oxidative stress and poor physiological recovery. This study examined the amount of lipid and protein oxidation during ischemia-reperfusion to assess the degree of oxidative stress. Selenium supplementation was used to alter the antioxidant status of rats and the recovery of myocardial function post ischemia-reperfusion was investigated. Male Wistar rats were fed diets containing 0, 50, and 1000 microg/kg sodium selenite for 5 weeks, whilst controls received normal rat food containing 240 microg/kg selenium. Langendorff-perfused hearts were subjected to 22.5 min global ischemia and 45 min reperfusion, with functional recovery assessed. Heart tissues were assayed for the presence of lipid peroxides and protein carbonyls and correlated to cardiac recovery. Following ischemia and reperfusion there was a significant increase in both protein oxidation and lipid peroxidation. Hearts from selenium-deficient animals demonstrated higher levels of both protein carbonyls and lipid peroxides and were more susceptible to ischemia-reperfusion injury when compared to controls (38% versus 47% recovery of rate pressure product (RPP)). Selenium supplementation lowered the levels of protein carbonyls and lipid peroxides and resulted in improved recovery of cardiac function post ischemia-reperfusion (57% recovery of RPP). These data suggest that selenium supplementation may provide an effective method for reducing oxidative damage post cardiac ischemia-reperfusion.
Authors:
Kylie Venardos; Glenn Harrison; John Headrick; Anthony Perkins
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Redox report : communications in free radical research     Volume:  9     ISSN:  1351-0002     ISO Abbreviation:  Redox Rep.     Publication Date:  2004  
Date Detail:
Created Date:  2005-02-21     Completed Date:  2005-07-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9511366     Medline TA:  Redox Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  317-20     Citation Subset:  IM    
Affiliation:
Heart Foundation Research Centre, Griffith University Gold Coast Campus, Southport, Queensland, Australia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Diet*
Heart / drug effects
Lipid Peroxidation / drug effects
Male
Myocardial Reperfusion Injury / drug therapy*,  metabolism,  physiopathology
Myocardium / metabolism
Oxidation-Reduction
Proteins / metabolism
Rats
Selenium / administration & dosage*,  deficiency
Chemical
Reg. No./Substance:
0/Proteins; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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