| Selenium and pseudoexfoliation syndrome. | |
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MedLine Citation:
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PMID: 21168825 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSE: To investigate the levels of selenium (Se), an essential trace element, in aqueous humor, conjunctival specimens, and serum of patients with pseudoexfoliation (PEX) syndrome and control subjects; and to determine the role of Se in the development and pathogenesis of PEX syndrome. DESIGN: A prospective case-control study. METHODS: Twenty-seven cataract patients with PEX syndrome and 20 age-matched cataract patients without PEX syndrome were enrolled in this institutional study. Patients with ophthalmic conditions other than PEX and conditions that may influence Se levels were excluded. During cataract surgeries, aqueous humor, conjunctival specimens, and serum were collected in both groups. Selenium levels of all samples were measured by using atomic absorption spectrophotometer. RESULTS: The mean Se levels in aqueous humor of patients with PEX syndrome (50.96 ± 23.79 μg/L) were significantly lower than the control group (77.85 ± 19.21 μg/L) (P < .001). The mean Se levels in conjunctival specimens of patients with PEX syndrome (4.04 ± 1.44 μg/mg) were significantly lower than the control group (7.19 ± 2.00 μg/mg) (P < .001), as well. The mean Se levels in serum of patients with PEX syndrome (115.25 ± 25.20 μg/L) were lower than the control group (124.25 ± 14.40 μg/L), but this was not statistically significant (P = .325). CONCLUSION: Reduced levels of Se in aqueous humor, conjunctival specimens, and serum of patients with PEX may support the role of impairment in antioxidant defense system in the pathogenesis of PEX syndrome. |
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Authors:
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Ayça Yilmaz; Lokman Ayaz; Lülüfer Tamer |
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Publication Detail:
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Type: Journal Article Date: 2010-12-18 |
Journal Detail:
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Title: American journal of ophthalmology Volume: 151 ISSN: 1879-1891 ISO Abbreviation: Am. J. Ophthalmol. Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-01-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370500 Medline TA: Am J Ophthalmol Country: United States |
Other Details:
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Languages: eng Pagination: 272-276.e1 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Ophthalmology, Mersin University Faculty of Medicine, Mersin, Turkey. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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