Document Detail

Selenium modifies glutathione peroxidase activity and glutathione concentration in mice exposed to ozone-provoked oxidative stress.
MedLine Citation:
PMID:  14531642     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to show the direct effect of selenium on glutathione peroxidase (GSH-Px) activity and GSH/GSSG concentrations in 3- and 6-month-old mice. An ozone-oxygen mixture was used to provoke an oxygen stress. To measure the Se-effect mice were gavaged with sodium selenite. GSH-Px activity and total glutathione concentrations were determined in serum and in the postnuclear fraction of liver and lungs. Additionally glutathione concentrations were determined in whole blood. Both ozone and selenium, administered separately, reduced GSH-Px activity in lungs of 6-month-old animals, while in young mice an opposite effect of Se was observed. Ozone administered jointly with Se did not influence GSH-Px activity in 6-month-old mice, while in young, 3-month-old mice, a stimulatory effect in lungs was observed. There were no significant changes in GSH-Px activity in the liver of 6-month-old mice, but the stimulatory effect occurred in young mice treated with Se and Se & ozone jointly. In young mice, ozone (also ozone with Se) augmented glutathione concentrations. The response to ozone and selenium strictly depended on age and the antagonism between selenium and ozone was observed only in a few cases.
Bogdan Dolezych; Elzbieta Szulinska
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)     Volume:  17     ISSN:  0946-672X     ISO Abbreviation:  J Trace Elem Med Biol     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-08     Completed Date:  2004-02-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9508274     Medline TA:  J Trace Elem Med Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  133-7     Citation Subset:  IM    
University of Silesia, Department of Animal Physiology & Ecotoxicology, Katowice, Poland.
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MeSH Terms
Glutathione / metabolism*
Glutathione Peroxidase / metabolism*
Lung / drug effects
Mice, Inbred Strains
Oxidants, Photochemical / metabolism*,  pharmacology
Oxidative Stress*
Ozone / metabolism*,  pharmacology
Selenium / metabolism*,  pharmacology
Reg. No./Substance:
0/Oxidants, Photochemical; 10028-15-6/Ozone; 70-18-8/Glutathione; 7782-49-2/Selenium; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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