| Selenium modifies glutathione peroxidase activity and glutathione concentration in mice exposed to ozone-provoked oxidative stress. | |
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MedLine Citation:
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PMID: 14531642 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to show the direct effect of selenium on glutathione peroxidase (GSH-Px) activity and GSH/GSSG concentrations in 3- and 6-month-old mice. An ozone-oxygen mixture was used to provoke an oxygen stress. To measure the Se-effect mice were gavaged with sodium selenite. GSH-Px activity and total glutathione concentrations were determined in serum and in the postnuclear fraction of liver and lungs. Additionally glutathione concentrations were determined in whole blood. Both ozone and selenium, administered separately, reduced GSH-Px activity in lungs of 6-month-old animals, while in young mice an opposite effect of Se was observed. Ozone administered jointly with Se did not influence GSH-Px activity in 6-month-old mice, while in young, 3-month-old mice, a stimulatory effect in lungs was observed. There were no significant changes in GSH-Px activity in the liver of 6-month-old mice, but the stimulatory effect occurred in young mice treated with Se and Se & ozone jointly. In young mice, ozone (also ozone with Se) augmented glutathione concentrations. The response to ozone and selenium strictly depended on age and the antagonism between selenium and ozone was observed only in a few cases. |
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Authors:
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Bogdan Dolezych; Elzbieta Szulinska |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) Volume: 17 ISSN: 0946-672X ISO Abbreviation: J Trace Elem Med Biol Publication Date: 2003 |
Date Detail:
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Created Date: 2003-10-08 Completed Date: 2004-02-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9508274 Medline TA: J Trace Elem Med Biol Country: Germany |
Other Details:
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Languages: eng Pagination: 133-7 Citation Subset: IM |
Affiliation:
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University of Silesia, Department of Animal Physiology & Ecotoxicology, Katowice, Poland. dolezych@us.edu.pl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Female Glutathione / metabolism* Glutathione Peroxidase / metabolism* Lung / drug effects Mice Mice, Inbred Strains Oxidants, Photochemical / metabolism*, pharmacology Oxidative Stress* Ozone / metabolism*, pharmacology Selenium / metabolism*, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Oxidants, Photochemical; 10028-15-6/Ozone; 70-18-8/Glutathione; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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