| Selenium metabolism in rats with long-term ingestion of Se-methylselenocysteine using enriched stable isotopes. | |
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MedLine Citation:
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PMID: 19336976 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Se-methylselenocysteine (MeSeCys) is not only a selenium (Se) supplement but also a more promising precursor of an anti-tumor drug containing Se than selenomethionine, which is currently used as Se supplement. In this study, the metabolism of MeSeCys labeled with an Se isotope, 82Se, in rats depleted of endogenous natural abundance isotopes with another Se isotope, 78Se, was traced for 21 days when MeSeCys was continuously and perorally ingested at a supplemental dose. The tracer experiment was performed with our improved method that utilized an inductively coupled plasma-deuterium reaction-mass spectrometer. The substitution of endogenous Se with a single isotope, 78Se, facilitated the detection of exogenous labeled Se. Exogenous Se in the form of MeSeCys preferably accumulated and/or assimilated in the liver, kidneys and testes with long-term ingestion of MeSeCys and was utilized for the synthesis of selenoproteins, i.e., extracellular and cellular glutathione peroxidases and selenoprotein P. Meanwhile, intact MeSeCys was not excreted into urine although trimethylselenonium was detected in addition to selenosugar. The results suggest that MeSeCys was transformed into selenide via methylselenol by beta-lyase. Consequently, it is surmised that MeSeCys is a precursor of methylselenol under long-term ingestion. |
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Authors:
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Yoshiro Tsuji; Noriyuki Suzuki; Kazuo T Suzuki; Yasumitsu Ogra |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of toxicological sciences Volume: 34 ISSN: 1880-3989 ISO Abbreviation: J Toxicol Sci Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-01 Completed Date: 2009-06-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7805798 Medline TA: J Toxicol Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 191-200 Citation Subset: IM |
Affiliation:
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Graduate School of Pharmaceutical Sciences, Chiba University. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cysteine / analogs & derivatives*, blood, pharmacokinetics, urine Isotopes / blood, diagnostic use, urine Kidney / drug effects, metabolism Liver / drug effects, metabolism Male Organoselenium Compounds / blood, pharmacokinetics*, urine Rats Rats, Wistar Selenium / blood, pharmacokinetics*, urine Tissue Distribution |
| Chemical | |
Reg. No./Substance:
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0/Isotopes; 0/Organoselenium Compounds; 2574-71-2/selenomethylselenocysteine; 52-90-4/Cysteine; 7782-49-2/Selenium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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