Document Detail

Selenium is inversely associated with bladder cancer risk: a report from the Belgian case-control study on bladder cancer.
MedLine Citation:
PMID:  16984549     Owner:  NLM     Status:  MEDLINE    
AIM: Selenium is an essential trace element with suspected anticarcinogenic properties in humans. To date, eight epidemiological studies have examined the association between serum selenium concentration and bladder cancer risk. METHODS: The authors carried out a population case-control study in 178 cases and 362 controls to assess the relationship between bladder cancer risk and selenium serum concentrations. Unconditional logistic regression was calculated to determine odds ratios (OR) for bladder cancer occurrence with corresponding 95% confidence intervals (95% CI). Effect modification by smoking status, low fruit and vegetable intake, retinol equivalent, vitamin C, vitamin E and total antioxidant status were also assessed. RESULTS: Serum selenium level was negatively associated with bladder cancer risk. After adjustment for sex, age, smoking and occupational exposure, the OR was 0.48 (95% CI 0.29-0.79) comparing the second with the lowest tertile (serum selenium concentration >82.40 microg/L). The adjusted OR for the highest tertile (serum selenium concentration >96.00 microg/L), was 0.30 (95% CI 0.17-0.52) (P-trend <0.001). An increase of 10 microg/L in serum selenium concentration was associated with a significant decreased bladder cancer risk (OR: 0.76; 95% CI 0.67-0.85). CONCLUSION: This case-control study suggests an inverse association between serum selenium concentration and bladder cancer risk.
Eliane Kellen; Maurice Zeegers; Frank Buntinx
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of urology : official journal of the Japanese Urological Association     Volume:  13     ISSN:  0919-8172     ISO Abbreviation:  Int. J. Urol.     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2006-09-20     Completed Date:  2007-01-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9440237     Medline TA:  Int J Urol     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  1180-4     Citation Subset:  IM    
Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Belgium.
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MeSH Terms
Belgium / epidemiology
Case-Control Studies
Middle Aged
Odds Ratio
Risk Factors
Selenium / blood*
Urinary Bladder Neoplasms / blood,  epidemiology*
Reg. No./Substance:

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