Document Detail

Selenium in global food systems.
MedLine Citation:
PMID:  11348568     Owner:  NLM     Status:  MEDLINE    
Food systems need to produce enough of the essential trace element Se to provide regular adult intakes of at least 40 microg/d to support the maximal expression of the Se enzymes, and perhaps as much as 300 microg/d to reduce risks of cancer. Deprivation of Se is associated with impairments in antioxidant protection, redox regulation and energy production as consequences of suboptimal expression of one or more of the Se-containing enzymes. These impairments may not cause deficiency signs in the classical sense, but instead contribute to health problems caused by physiological and environmental oxidative stresses and infections. At the same time, supranutritional intakes of Se, i.e. intakes greater than those required for selenocysteine enzyme expression, appear to reduce cancer risk. The lower, nutritional, level is greater than the typical intakes of many people in several parts of the world, and few populations have intakes approaching the latter, supranutritional, level. Accordingly, low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates.
G F Combs
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The British journal of nutrition     Volume:  85     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2001 May 
Date Detail:
Created Date:  2001-05-11     Completed Date:  2001-06-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  517-47     Citation Subset:  IM    
Department of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Biological Availability
Cardiomyopathies / etiology,  prevention & control
Cartilage Diseases / etiology
Dietary Supplements
Food Supply
Neoplasms / prevention & control
Nutritional Physiological Phenomena*
Nutritional Status
Selenium* / administration & dosage,  deficiency,  metabolism
World Health*
Reg. No./Substance:
0/Soil; 7782-49-2/Selenium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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