Document Detail

Selenium deficiency.
MedLine Citation:
PMID:  3933865     Owner:  NLM     Status:  MEDLINE    
Selenium is undoubtedly an essential trace element: its involvement in GPx structure, the presence of deleterious effects of selenium deficiency in animals, and the recognition of deficiency states in man attest to its importance. However, if the consequences of selenium deficiency in man are now widely recognized, the mechanisms underlying these conditions are poorly understood. The definition of the exact role of selenium in human homeostasis has been hampered by the lack of a sensitive parameter, usable in routine investigation, to assess selenium status. Measurements of plasma and urinary levels, although useful in clinical practice, are inadequate indicators. The only true evidence of selenium deficiency lies in a positive response to selenium therapy. Deficiency states have been demonstrated for inhabitants of regions where selenium supply is limited, in protein-energy malnutrition, and in patients maintained on total parenteral nutrition without selenium supplementation. The benefit of selenium supplementation, together with other antioxidant drugs, in non-deficient subjects is still a matter of debate; its protective effect in neoplastic, cardiovascular and neurological degenerative diseases is not yet proven.
J Nève; F Vertongen; L Molle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinics in endocrinology and metabolism     Volume:  14     ISSN:  0300-595X     ISO Abbreviation:  Clin Endocrinol Metab     Publication Date:  1985 Aug 
Date Detail:
Created Date:  1986-01-09     Completed Date:  1986-01-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0357424     Medline TA:  Clin Endocrinol Metab     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  629-56     Citation Subset:  IM    
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MeSH Terms
Antioxidants / therapeutic use
Blood Platelets / metabolism
Cardiovascular Diseases / etiology
Erythrocytes / metabolism
Glutathione Peroxidase / metabolism
Hematologic Diseases / etiology
Infant, Newborn
Liver / metabolism
Metalloproteins / metabolism
Metals / metabolism
Muscular Diseases / etiology
Neoplasms / etiology
Nervous System Diseases / etiology
Nutritional Requirements
Parenteral Nutrition, Total
Selenium / administration & dosage,  deficiency*,  metabolism,  physiology,  therapeutic use
Reg. No./Substance:
0/Antioxidants; 0/Metalloproteins; 0/Metals; 7782-49-2/Selenium; EC Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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