Document Detail

Selenium deficiency in a patient with Crohn's disease receiving long-term total parenteral nutrition.
MedLine Citation:
PMID:  12636234     Owner:  NLM     Status:  MEDLINE    
We report a case of selenium deficiency in a patient with Crohn's disease on long-term total parenteral nutrition (TPN). She manifested lassitude of the legs, discoloration of the nail beds, and macrocytosis. Since her plasma selenium level was found to be below the measurable level, we diagnosed this case as selenium deficiency. After intravenous administration of sodium selenite, her symptoms were reversed. Careful attention should be paid to selenium deficiency when a patient receives long-term TPN; supplementary administration of selenium via TPN may be required because selenium is often not routinely added to TPN formulations.
Tetsuya Ishida; Katsuro Himeno; Yasuko Torigoe; Megumi Inoue; Osamu Wakisaka; Takuo Tabuki; Hidenobu Ono; Koichi Honda; Tetsu Mori; Masataka Seike; Hironobu Yoshimatsu; Toshiie Sakata
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  42     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-03-14     Completed Date:  2003-06-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  154-7     Citation Subset:  IM    
Department of Internal Medicine I, School of Medicine, Oita Medical University, Oita.
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MeSH Terms
Colectomy / adverse effects,  methods
Crohn Disease / diagnosis*,  surgery
Deficiency Diseases / diagnosis*,  drug therapy,  etiology
Dietary Supplements
Follow-Up Studies
Long-Term Care
Parenteral Nutrition / adverse effects*,  methods
Risk Assessment
Selenium / deficiency*
Severity of Illness Index
Short Bowel Syndrome / etiology,  therapy*
Sodium Selenite / therapeutic use*
Treatment Outcome
Reg. No./Substance:
10102-18-8/Sodium Selenite; 7782-49-2/Selenium

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