| Selenium-containing naphthalimides as anticancer agents: Design, synthesis and bioactivity. | |
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MedLine Citation:
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PMID: 22436386 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Selenium analogues (4b-4h, and 4j) of two known sulfur compounds were synthesized and tested their anticancer activities. The selenium compound 4b had comparable activity with its sulfur analogue 4a, while DNA-binding study showed these two compounds had similar interaction with ct-DNA, the K(b) was 8.23 and 2.36, respectively. The primary results showed that most compounds had moderate anticancer activities with IC(50) values between 10(-6) and 10(-5)M. Another selenium analogue 4j showed the highest activity with the IC(50) values around 5.3μM against K562 and MCF-7 cell lines. More importantly, the organochalcogen compounds exhibited stronger anticancer activities against K562 cell line than the other cell lines tested. |
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Authors:
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Liwei Zhao; Jianfeng Li; Yiquan Li; Jianwen Liu; Thomas Wirth; Zhong Li |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-3-1 |
Journal Detail:
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Title: Bioorganic & medicinal chemistry Volume: - ISSN: 1464-3391 ISO Abbreviation: - Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-3-22 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9413298 Medline TA: Bioorg Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Shanghai Key Lab of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Meilong Road 130, Shanghai 200237, China; School of Chemistry, Cardiff University, Park Place, Cardiff CF10 3AT, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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