Document Detail


Selenium compound protects corneal epithelium against oxidative stress.
MedLine Citation:
PMID:  23049824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ocular surface is strongly affected by oxidative stress, and anti-oxidative systems are maintained in corneal epithelial cells and tear fluid. Dry eye is recognized as an oxidative stress-induced disease. Selenium compound eye drops are expected to be a candidate for the treatment of dry eye. We estimated the efficacy of several selenium compounds in the treatment of dry eye using a dry eye rat model. All of the studied selenium compounds were uptaken into corneal epithelial cells in vitro. However, when the selenium compounds were administered as eye drops in the dry eye rat model, most of the selenium compounds did not show effectiveness except for Se-lactoferrin. Se-lactoferrin is a lactoferrin that we prepared that binds selenium instead of iron. Se-lactoferrin eye drops suppressed the up-regulated expression of heme oxygenase-1, cyclooxygenase-2, matrix metallopeptidase-9, and interleukin-6 and also suppressed 8-OHdG production in the cornea induced by surgical removal of the lacrimal glands. Compared with Se-lactoferrin, apolactoferrin eye drops weakly improved dry eye in high dose. The effect of Se-lactoferrin eye drops on dry eye is possibly due to the effect of selenium and also the effect of apolactoferrin. Se-lactoferrin is a candidate for the treatment of dry eye via regulation of oxidative stress in the corneal epithelium.
Authors:
Akihiro Higuchi; Hiroyoshi Inoue; Tetsuya Kawakita; Tadashi Ogishima; Kazuo Tsubota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-25
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-10     Completed Date:  2013-04-22     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e45612     Citation Subset:  IM    
Affiliation:
Shinanomachi Research Park 6N9, Center for Integrated Medical Research, Keio University, School of Medicine, Tokyo, Japan. ahiguchi@z6.keio.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Cells, Cultured
Cornea / drug effects*,  metabolism,  pathology
Cyclooxygenase 2 / genetics,  metabolism
Deoxyguanosine / analogs & derivatives,  antagonists & inhibitors,  biosynthesis
Disease Models, Animal
Dry Eye Syndromes / drug therapy*,  metabolism,  pathology
Epithelial Cells / drug effects*,  metabolism,  pathology
Epithelium, Corneal / drug effects*,  metabolism,  pathology
Gene Expression / drug effects
Heme Oxygenase-1 / genetics,  metabolism
Humans
Interleukin-6 / agonists,  genetics,  metabolism
Lacrimal Apparatus / surgery
Lactoferrin / chemistry,  pharmacology*
Male
Matrix Metalloproteinase 9 / genetics,  metabolism
Ophthalmic Solutions
Oxidative Stress / drug effects
Rats
Rats, Sprague-Dawley
Selenium / chemistry,  pharmacology*
Chemical
Reg. No./Substance:
0/8-hydroxy-2'-deoxyguanosine; 0/Interleukin-6; 0/Ophthalmic Solutions; 7782-49-2/Selenium; 961-07-9/Deoxyguanosine; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.3/Heme Oxygenase-1; EC 3.4.21.-/Lactoferrin; EC 3.4.24.35/Matrix Metalloproteinase 9
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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