| Selenium bioavailability from soy protein isolate and tofu in rats fed a torula yeast-based diet. | |
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MedLine Citation:
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PMID: 19919094 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Selenium (Se) is an essential nutrient, and soy is a major plant source of dietary protein to humans. The United States produces one-third of the world's soybeans, and the Se-rich Northern Plains produce a large share of the nation's soybeans. The present study used a rat model to determine the bioavailability of Se from a protein isolate and tofu (bean curd) prepared from a soybean cultivar we recently developed specifically for food grade markets. The soybean seeds contained 2.91 mg Se/kg. Male Sprague-Dawley rats were depleted of Se by feeding them a 30% Torula yeast-based diet containing 5 microg Se/kg; after 56 days, they were replenished of Se for an additional 50 days by feeding them the same diet supplemented with 20, 30, or 40 microg Se/kg from soy protein isolate or tofu. l-Selenomethionine (SeMet) was used as a reference. Selenium bioavailability was determined on the basis of the responses of Se-dependent enzyme activities and tissue Se contents, comparing those responses for each soy product to those for SeMet using a slope-ratio method. Dietary supplementation with the protein isolate or tofu resulted in dose-dependent increases in glutathione peroxidase activities in blood and liver and thioredoxin reductase activity in liver, as well as dose-dependent increases in the Se contents of plasma, liver, muscle, and kidneys. These responses indicated an overall bioavailability of approximately 97% for Se from both the protein isolate and tofu, relative to SeMet. These results demonstrate that Se from this soybean cultivar is highly bioavailable in this model and that high-Se soybeans can be good dietary sources of Se. |
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Authors:
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Lin Yan; George L Graef; Philip G Reeves; LuAnn K Johnson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of agricultural and food chemistry Volume: 57 ISSN: 1520-5118 ISO Abbreviation: J. Agric. Food Chem. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-16 Completed Date: 2010-03-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0374755 Medline TA: J Agric Food Chem Country: United States |
Other Details:
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Languages: eng Pagination: 11575-80 Citation Subset: IM |
Affiliation:
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U.S. Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202, USA. lin.yan@ars.usda.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Availability Candida* / chemistry, metabolism Diet* Dietary Proteins / metabolism Glutathione Peroxidase / blood, metabolism Liver / enzymology Male Organ Specificity Rats Selenium / analysis, blood, deficiency, pharmacokinetics* Soy Foods* / analysis Soybean Proteins / administration & dosage*, isolation & purification, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Soybean Proteins; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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